Evidence map›Paper›PMID 39198343›Full record

ArticleEndocrine2025

Resveratrol stimulates brown of white adipose via regulating ERK/DRP1-mediated mitochondrial fission and improves systemic glucose homeostasis.

Hongjia Yan, Muqing Shao, Xiaoqian Lin, Ting Peng, Caiyu Chen, Mei Yang, Jian Zhong, Jian Yang, Suocheng Hui

Abstract read
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In one paragraph

Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Gut Microbiota-Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongjia Yan *Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Muqing Shao *Department of Endocrinology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaoqian LinDepartment of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ting PengDepartment of Clinical Nutrition, The People's Hospital of Chongqing Liang Jiang New Area, Chongqing, China.
Caiyu ChenDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.
Mei YangDepartment of Endocrinology, The People's Hospital of Chongqing Liang Jiang New Area, Chongqing, China.
Jian ZhongDepartment of Endocrinology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jian YangDepartment of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China. jianyang@hospital.cqmu.edu.cn.
Suocheng HuiDepartment of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China. suochenghui@cqmu.edu.cn.

Funding

National Natural Science Foundation of China 82103845Natural Science Foundation of Chongqing of China 2024NSCQ-MSX1776Natural Science Foundation of Chongqing of China CSTB2022NSCQ-BHX0013Postdoctoral Research Project by Administration Human Resources and Social Security of Chongqing 2021XM3104Program of Chongqing Medical University for Youth Innovation in Future Medicine W0085
6 · The paper itself

Abstract

purposeDiabetes mellitus and metabolic homeostasis disorders may benefit from white adipose tissue (WAT) browning, which is associated with mitochondrial fission. Resveratrol, a dietary polyphenol, exhibits beneficial effects against abnormalities related to metabolic diseases. However, it remains unknown whether resveratrol contributes to WAT browning by regulating mitochondrial fission.

methodsWe administered resveratrol (0.4% mixed with control) to db/db mice for 12 weeks, measuring body weight, oral glucose tolerance, insulin tolerance, and histological changes. The uncoupling protein 1 (UCP1) and dynamin-related protein 1 (DRP1) expressions in the epididymal WAT were assessed via immunoblotting.

resultsWe found that resveratrol improved systemic glucose homeostasis and insulin resistance in db/db mice, which was associated with increased UCP1 in epididymal WAT. Resveratrol-treated mice exhibited more fragmented mitochondria and increased phosphorylation of DRP1 in the epididymal WAT of the db/db mice. These results were further confirmed in vitro, where resveratrol induced extracellular signal-regulated kinase (ERK) signaling activation, leading to phosphorylation of DRP1 at the S616 site (p-DRP1

conclusionResveratrol plays a role in regulating the phosphorylation of ERK and DRP1, resulting in the promotion of beige cells with epididymal WAT and the improvement of glucose homeostasis. Our present study provides novel insights into the potential mechanism of resveratrol-mediated effects on WAT browning, suggesting that it is, at least in part, mediated through ERK/DRP1-mediated mitochondrial fission.

Indexed as

Adipose Tissue, BrownAdipose Tissue, WhiteDynaminsGlucoseMAP Kinase Signaling SystemMitochondrial DynamicsResveratrol3T3-L1 CellsAnimalsHomeostasisInsulin ResistanceMaleMiceMice, Inbred C57BLUncoupling Protein 1Dnm1l protein, mouseDynaminsGlucoseResveratrolUncoupling Protein 1Adipose browningGlucose homeostasisMitochondrial fissionResveratrol

Identifiers

PMID39198343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.