Evidence map›Paper›PMID 39198173›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Interleukin-6 Immunology in Macrophage Activation Syndrome Related to Neuroimmunological Diseases.

Taichi Nomura, Masaaki Niino, Toshio Odani, Ryoji Naganuma, Itaru Amino, Yusei Miyazaki, Sachiko Akimoto, Zen-Ichi Tanei, Taichi Kimura, Naoya Minami and 1 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Taichi NomuraDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.
Masaaki NiinoDepartment of Clinical Research, National Hospital Organization Hokkaido Medical Center, Japan.
Toshio OdaniDepartment of Rheumatology, National Hospital Organization Hokkaido Medical Center, Japan.
Ryoji NaganumaDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.
Itaru AminoDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.
Yusei MiyazakiDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.
Sachiko AkimotoDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.
Zen-Ichi TaneiDepartment of Cancer Pathology, Faculty of Medicine, Hokkaido University, Japan.
Taichi KimuraDepartment of Pathology, National Hospital Organization Hokkaido Medical Center, Japan.
Naoya MinamiDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.
Seiji KikuchiDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophage activation syndrome (MAS) involves an excessive amount of acute inflammatory responses to inflammatory cytokines, particularly interleukin-6 (IL-6). IL-6 is also strongly associated with the pathophysiology of certain neuroimmunological diseases. However, there have so far been few reports of MAS being accompanied by neuroimmunological diseases. We herein report two cases of MAS comorbid with myasthenia gravis or neuromyelitis optica spectrum disorders, IL-6 related neuroimmunological diseases. Standard immunosuppressive therapies could not stabilize the symptoms in our cases until antibodies against the IL-6 receptor were administered. This finding suggests that it is important to consider the underlying pathophysiology of MAS in relation to these neuroimmunological diseases when treating affected patients.

Indexed as

Interleukin-6Macrophage Activation SyndromeMyasthenia GravisNeuromyelitis OpticaHumansInterleukin-6interleukin-6macrophage activation syndromemyasthenia gravisneuromyelitis optica spectrum disorders

Identifiers

PMID39198173
PMCPMC11986307

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.