Evidence map›Paper›PMID 39198169›Full record

ArticleInternal medicine (Tokyo, Japan)2025

T-cell Large Granular Lymphocytic Leukemia with a STAT3 Mutation Successfully Treated with Cord Blood Transplantation.

Yoshihiro Tokunaga, Yukinori Nakamura, Taishi Ando, Kensaku Katsuki, Kohei Sakai, Yuka Fujioka, Shota Nono, Takahiro Sasaki, Kaoru Yamamoto, Masaru Akiyama and 5 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yoshihiro TokunagaThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Yukinori NakamuraThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Taishi AndoThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Kensaku KatsukiDivision of Hematology and Diabetes, Nagato General Hospital, Japan.
Kohei SakaiThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Yuka FujiokaThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Shota NonoThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Takahiro SasakiDepartment of Hematology, Shuto General Hospital, Japan.
Kaoru YamamotoThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Masaru AkiyamaThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Fumihiro KawakamiDepartment of Hematology and Clinical Oncology, Shinshu University School of Medicine, Japan.
Toru KawakamiDepartment of Hematology and Clinical Oncology, Shinshu University School of Medicine, Japan.
Fumihiro IshidaDepartment of Hematology and Clinical Oncology, Shinshu University School of Medicine, Japan.
Yasuharu OhtaThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.
Toshiaki YujiriThird Department of Internal Medicine, Yamaguchi University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 64-year-old woman presented with agranulocytosis, anemia, and bacteremia, leading to a diagnosis of T-cell large granular lymphocytic leukemia (T-LGLL). A molecular analysis identified a signal transducer and activator of transcription 3 (STAT3) Y640F variant. Initial treatment with cyclophosphamide and prednisolone did not improve her condition, but serious infections were observed. The patient underwent cord blood transplantation (CBT) after preconditioning with fludarabine, busulfan, and total body irradiation, yielding a STAT3 Y640F variant disappearance, based on allele-specific quantitative polymerase chain reaction (AS-qPCR). In this case, CBT is a promising refractory T-LGLL treatment option, and the STAT3 Y640F variant AS-qPCR is a T-LGLL activity marker.

Indexed as

Cord Blood Stem Cell TransplantationLeukemia, Large Granular LymphocyticMutationSTAT3 Transcription FactorFemaleHumansMiddle AgedTreatment OutcomeSTAT3 protein, humanSTAT3 Transcription Factorallele-specific quantitative PCRcord blood transplantationsignal transducer and activator of transcription 3 (STAT3)T-cell large granular lymphocytic leukemia

Identifiers

PMID39198169
PMCPMC11867745

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.