Evidence map›Paper›PMID 39197836›Full record

ArticleJournal of the American Chemical Society2024

The Dual Mode of Antibacterial Action of the Synthetic Small Molecule DCAP Involves Lipid II Binding.

Kevin C Ludwig, Jan-Samuel Puls, Cruz L Matos de Opitz, Paolo Innocenti, Jan-Martin Daniel, Jan Bornikoel, Melina Arts, Sebastian Krannich, Jan Straetener, Dominik Brajtenbach and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Bacterial cell envelope-targeting antibiotics.Nature reviews. Microbiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kevin C LudwigInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.ORCID 0000-0003-3534-0729
Jan-Samuel PulsInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.ORCID 0000-0002-8130-7375
Cruz L Matos de OpitzDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology & Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.ORCID 0000-0002-0098-2783
Paolo InnocentiBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, the Netherlands.
Jan-Martin DanielInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.
Jan BornikoelDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology & Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Melina ArtsInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.ORCID 0000-0003-0344-6107
Sebastian KrannichInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.
Jan StraetenerDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology & Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Dominik BrajtenbachClausius-Institute for Physical and Theoretical Chemistry, University of Bonn, Wegelerstraße 12, 53115 Bonn, Germany.
Beate HenrichfreiseInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.
Peter SassDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology & Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.ORCID 0000-0002-4477-2382
Anna MuellerInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.
Nathaniel I MartinBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, the Netherlands.ORCID 0000-0001-8246-3006
Heike Brötz-OesterheltDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology & Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.ORCID 0000-0001-9364-1832
Ulrich KubitscheckClausius-Institute for Physical and Theoretical Chemistry, University of Bonn, Wegelerstraße 12, 53115 Bonn, Germany.
Fabian GreinInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.
Tanja SchneiderInstitute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.ORCID 0000-0001-7269-4716

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthetic small molecule DCAP is a chemically well-characterized compound with antibiotic activity against Gram-positive and Gram-negative bacteria, including drug-resistant pathogens. Until now, its mechanism of action was proposed to rely exclusively on targeting the bacterial membrane, thereby causing membrane depolarization, and increasing membrane permeability (Eun

Indexed as

Anti-Bacterial AgentsMicrobial Sensitivity TestsUridine Diphosphate N-Acetylmuramic AcidCell WallMolecular StructureSmall Molecule LibrariesAnti-Bacterial Agentsmuramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenolSmall Molecule LibrariesUridine Diphosphate N-Acetylmuramic Acid

Identifiers

PMID39197836
PMCPMC11403595

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.