ArticleAcademic pediatrics
Anxiety and Depression Symptoms, Adverse Childhood Experiences, and Persistent/Recurrent Pain Across Early Adolescence.
Article in Academic pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Understanding adverse childhood experiences within the first decade of the ABCD study: A systematic review.Developmental cognitive neuroscience · 2026Pooled it
- Understanding fibromyalgia beyond pain: emotional imbalance and the case for compassionate care.RMD open · 2026Review
- Adverse and positive childhood experiences and suicidal ideation onset in a US pre-early adolescent cohort.BMC medicine · 2026Article
- The role of sleep deficiency in the relationship between adverse childhood experiences and early adolescent pain outcomes.JCPP advances · 2025Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
objectiveTo determine whether anxiety and depression symptoms are mechanisms through which adverse childhood experiences (ACEs) contribute toward persistent/recurrent pain (PRP) across early adolescence.
methodsThis study described the direct and indirect (ie, mediated) effects of ACEs on PRP across early adolescence, using 4 years of Adolescent Brain Cognitive Development Study data. Annual pain frequency, anxiety, and depression symptoms were measured using the Child Behavior Checklist, and youth with pain for ≥3 of the 4-year study period were classified with PRP. Early (up to age 9-10 years; reported at baseline) and recent (at age 10-11 years; reported at year 1) ACE exposures were derived from parent and youth completed surveys. Structural equation modeling estimated the direct and indirect associations among early and recent ACEs, pain outcomes, and anxiety/depression symptoms reported in the year(s) in between.
resultsAmong 7951 youth, 2540 (31.9%) were classified with PRP. Higher levels of early ACE exposure were associated with an increased probability of having PRP (adj. β 0.65 [95% confidence interval {CI} 0.07, 1.22). Early ACEs also had indirect effects on PRP via higher interim anxiety (adj. β 5.36 [95% CI 3.45, 7.26]) and depression symptoms (adj. β 4.57 [95% CI 3.01, 6.13]). Early and recent ACE exposures predicted higher pain frequency scores in subsequent years, with mixed results regarding the role of anxiety and depression in the relationships between ACEs and pain frequency scores.
conclusionsAnxiety and depression symptoms are potentially important interventional targets to lower the risk for PRP among youth exposed to ACEs.
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