ArticleCell host & microbe2024
Clinical sequelae of gut microbiome development and disruption in hospitalized preterm infants.
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Article in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
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33citing papers in PubMed
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Who cites it
33 citing papers in PubMed.
- Early-life colonization withScience (New York, N.Y.) · 2026Article
- Gut microbiota alterations in Neonatal Intensive Care Unit extremely preterm infants: a Chinese tertiary center study.Translational pediatrics · 2026Article
- Single-cell detection and quantification of the microbiota by MicFLY.Cell host & microbe · 2026Article
- Maternal and infant gut microbiome.iMeta · 2026Review
- From homeostasis to dysregulation: human milk, microbial metabolites, and the preterm intestinal microenvironment in necrotizing enterocolitis.Translational pediatrics · 2026Review
- Antibiotic-Driven Gut Microbiome Dysbiosis: Resistome Dynamics, Metabolic Disruption, and Paths to Restoration.Antibiotics (Basel, Switzerland) · 2026Review
- Associations between fentanyl exposure, gut microbiome and neurodevelopmental outcomes in preterm infants.Pediatric research · 2026Article
- Meconium Microbiome Maturation Patterns Linked to Postnatal Growth Failure in Neonates.Nutrients · 2026Article
- Gut dysbiosis associated with neonatal respiratory distress syndrome and biological plausibility of disease-specific probiotic intervention: a translational study.Journal of translational medicine · 2026Article
- An ubiquitous antibacterial toxin from human gut bacteria engenders neonatal colonization advantage.Nature communications · 2026Article
- Factors influencing preterm infant microbiota and their role in wheezing development.Pediatric research · 2026Article
- A Potential Gut-Retina Axis in Retinopathy of Prematurity: Emerging Perspectives on Microbiome-Mediated Modulation of the IGF-1-VEGF Pathway.International journal of molecular sciences · 2026Review
- Article
- Host genetic variation and gut microbiome in pediatric diseases.Chinese medical journal · 2026Review
- Tracing the early bacterial settlers in preterm and very-low birth-weight infants: first report of microbiota dynamics in South American neonates.Infection and immunity · 2026Article
- Early-Life Gut Microbiota: Education of the Immune System and Links to Autoimmune Diseases.Microorganisms · 2026Review
- Optimising the induction of inflammation within preterm infant-derived intestinal epithelial organoids.Npj gut and liver · 2026Article
- Day-21 gut microbiota community state types are associated with bronchopulmonary dysplasia classification in preterm infants: a pilot shotgun metagenomic study.Frontiers in microbiology · 2026Article
- GGut microbes · 2025Review
- Article
Corrections and comments
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Authors and funding
17 authors.
Robert ThänertThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Drew J SchwartzThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Diseases Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Eric C KeenThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Carla Hall-MooreDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bin WangThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nurmohammad ShaikhDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jie NingThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
L Colleen Rouggly-NicklessDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Anna ThänertThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Aura FerreiroThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Skye R S FishbeinThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Janice E SullivanDepartment of Pediatrics, University of Louisville School of Medicine, Norton Children's Hospital, Louisville, KY 40202, USA.
Paula RadmacherDepartment of Pediatrics, University of Louisville School of Medicine, Norton Children's Hospital, Louisville, KY 40202, USA.
Marilyn EscobedoDepartment of Pediatrics, University of Oklahoma, Oklahoma City, OK 73104, USA.
Barbara B WarnerDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: warnerbb@wustl.edu.
Phillip I TarrDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: tarr@wustl.edu.
Gautam DantasThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address: dantas@wustl.edu.
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8MUniversity of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0MThe Neonatal Microbiome and Necrotizing EnterocolitisUH3AI083265 · NIAID · WASHINGTON UNIVERSITY · PI TARR, PHILLIP I · 2010 to 2012
$7.6MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MImpact of early-life perturbations on pediatric microbiome maturationR01AI155893 · NIAID · WASHINGTON UNIVERSITY · PI Gautam Dantas · 2021 to 2026
$4.6MPHYLOGENOMIC, TRANSCRIPTOMIC, VIROMIC, AND IMMUNOPROTEOMIC DETERMINANTS OF NECROTIZING ENTEROCOLITISR01HD092414 · NICHD · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, TARR, PHILLIP I · 2017 to 2021
$3.0MHigh-resolution genomic interrogation of pathogen-microbiome interactions in Clostridioides difficile infectionR01AI184858 · NIAID · WASHINGTON UNIVERSITY · PI ERIK R DUBBERKE, Gautam Dantas · 2024 to 2026
$2.3MPEDIATRIC GASTROENTEROLOGY RESEARCH TRAININGT32HD007409 · NICHD · WASHINGTON UNIVERSITY · PI TARR, PHILLIP I · 1991 to 2005
$978kAntibiotic disruption of the gut microbiome and immune response in neonatal late-onset sepsisK08AI159384 · NIAID · WASHINGTON UNIVERSITY · PI SCHWARTZ, DREW JOEL · 2021 to 2025
$785kIdentifying sources of variation in microbiome-pathogen dynamics during Clostridioides difficile colonizationK99AI175674 · NIAID · WASHINGTON UNIVERSITY · PI FISHBEIN, SKYE REBECCA · 2024 to 2024
$126kDoris Duke Charitable Foundation 2021081NIAID NIH HHS K08 AI159384NIAID NIH HHS K99 AI175674NIAID NIH HHS R01 AI155893NIAID NIH HHS R01 AI184858NIAID NIH HHS UH3 AI083265NICHD NIH HHS R01 HD092414NICHD NIH HHS T32 HD007409NIDDK NIH HHS P30 DK052574NIDDK NIH HHS T32 DK077653NIEHS NIH HHS P30 ES030283
Abstract
Aberrant preterm infant gut microbiota assembly predisposes to early-life disorders and persistent health problems. Here, we characterize gut microbiome dynamics over the first 3 months of life in 236 preterm infants hospitalized in three neonatal intensive care units using shotgun metagenomics of 2,512 stools and metatranscriptomics of 1,381 stools. Strain tracking, taxonomic and functional profiling, and comprehensive clinical metadata identify Enterobacteriaceae, enterococci, and staphylococci as primarily exploiting available niches to populate the gut microbiome. Clostridioides difficile lineages persist between individuals in single centers, and Staphylococcus epidermidis lineages persist within and, unexpectedly, between centers. Collectively, antibiotic and non-antibiotic medications influence gut microbiome composition to greater extents than maternal or baseline variables. Finally, we identify a persistent low-diversity gut microbiome in neonates who develop necrotizing enterocolitis after day of life 40. Overall, we comprehensively describe gut microbiome dynamics in response to medical interventions in preterm, hospitalized neonates.
Indexed as
Anti-Bacterial AgentsEnterocolitis, NecrotizingFecesGastrointestinal MicrobiomeInfant, PrematureMetagenomicsBacteriaClostridioides difficileEnterobacteriaceaeEnterococcusFemaleHospitalizationHumansInfantInfant, NewbornIntensive Care Units, NeonatalAnti-Bacterial Agentsantibioticsexposomegut microbiomemetagenomicsmetatranscriptomicsmicrobiome shiftsnecrotizing enterocolitisneonatal intensive care unitpreterm infants
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