ArticleACS synthetic biology2024
Approaching Optimal pH Enzyme Prediction with Large Language Models.
Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Niche Construction: A Rational Engineering Strategy for Regulating Microbial Assembly to Enhance Flavor and Bioactivity of Fermented Foods.Comprehensive reviews in food science and food safety · 2026Review
- EnzymeMiner 2.0: advancing automated enzyme discovery with expansive sequence mining and smart property analysis.Nucleic acids research · 2026Article
- Electrostatic tuning of the pyridoxal-5'-phosphate cofactor site defines pH dependence in type I cystathionine β-lyases.The Journal of biological chemistry · 2026Article
- Changes in the pH-Activity Profiles of Enzymes upon Immobilization on Polyelectrolyte-Containing Hydrogels.Chem & bio engineering · 2026Article
- Machine learning for enzyme catalytic activity: current progress and future horizons.Briefings in bioinformatics · 2026Review
- Leveraging artificial intelligence for efficient microbial production.Bioresource technology · 2026Review
- Deep Learning-Based Prediction of Enzyme Optimal pH and Design of Point Mutations to Improve Acid Resistance.ACS synthetic biology · 2025Article
- Inactivation of Listeria monocytogenes and Salmonella Typhimurium by piezoelectric cold plasma: oxidative, structural and metabolic pathways.Archives of microbiology · 2025Article
- aMLProt: an automated machine learning library for protein applications.Bioinformatics (Oxford, England) · 2025Article
- A Deep Retrieval-Enhanced Meta-Learning Framework for Enzyme Optimum pH Prediction.Journal of chemical information and modeling · 2025Article
- Computation suggests that the cell adhesion sub-proteome is enriched for sites of pH-dependence and charge burial.PloS one · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enzymes are widely used in biotechnology due to their ability to catalyze chemical reactions: food making, laundry, pharmaceutics, textile, brewing─all these areas benefit from utilizing various enzymes. Proton concentration (pH) is one of the key factors that define the enzyme functioning and efficiency. Usually there is only a narrow range of pH values where the enzyme is active. This is a common problem in biotechnology to design an enzyme with optimal activity in a given pH range. A large part of this task can be completed
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Registered trials
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