SynthesisPloS one2024
Population-based screening strategies for biliary atresia in the newborn: A systematic review and meta-analysis.
Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Biliary Atresia With Situs Inversus Abdominalis Managed by Kasai Portoenterostomy: A Case Report From Muhimbili National Hospital, Tanzania.Clinical case reports · 2026Article
- Diagnostic and management guidelines for biliary atresia in 2025.Hepatobiliary surgery and nutrition · 2026Review
- Conjugated Hyperbilirubinemia in Early Infancy: Rethinking Diagnostic Cut-Offs-A Retrospective Analysis.International journal of neonatal screening · 2026Article
- Integrated transcriptomic and co-expression network analysis identifiesTranslational pediatrics · 2025Article
- European strategies in the screening of biliary atresia: a scoping review.World journal of pediatric surgery · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundNewborn screening for biliary atresia (BA) may facilitate earlier diagnosis and intervention for improved clinical outcomes.
methodsWe systematically reviewed the accuracy of population-based screening strategies for BA in the newborn using PRISMA-DTA guidelines. We included cohort or cross-sectional studies. The screening (index) tests included stool color card (SCC) and direct/conjugated bilirubin (DB/CB) and the reference standard was intraoperative cholangiogram. Meta-analysis was performed using random-effects logistic regression models.
resultsWe included 15 studies (1,816,722 participants) that assessed 5 different population-based screening strategies. QUADAS-2 assessment revealed high risk of bias for patient selection in one study and uncertain risks for reference standard in multiple studies. High certainty evidence suggests that DB/CB assessed after birth had a summary sensitivity of 100% (95% CI 100,100) and specificity of 98.8% (98.8,98.9) (5 studies, 662141 participants). Moderate certainty evidence suggests that SCC screening at a month of age had summary sensitivity of 79.6% (95% CI 70.6, 86.4) and specificity of 99.9% (95% CI 99.9, 99.9) (7 studies, 996262 participants).
conclusionsDB/CB in the first few days of life has the best diagnostic accuracy for population screening for biliary atresia in the newborn. Future research should focus on cost-effectiveness and combinations of screening strategies.
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