Evidence map›Paper›PMID 39196997›Full record

ArticleOrganic letters2024

Aryne Aminohalogenation Using Protic Amines Enabled by Halogen Transfer.

Joshua T Gavin, Lars W Anderson, Courtney C Roberts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joshua T GavinDepartment of Chemistry, University of Minnesota─Twin Cities, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-7122-324X
Lars W AndersonDepartment of Chemistry, University of Minnesota─Twin Cities, Minneapolis, Minnesota 55455, United States.
Courtney C RobertsDepartment of Chemistry, University of Minnesota─Twin Cities, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-8177-4013

Funding

Methods for Selective Functionalization of (Hetero)arene RingsR35GM146957 · NIGMS · UNIVERSITY OF MINNESOTA · PI Courtney C Roberts · 2022 to 2026
$1.9M
Upgrade of a 500 MHz NMR Spectrometer for Applications in Biomedical ResearchS10OD011952 · OD · UNIVERSITY OF MINNESOTA · PI HOYE, THOMAS R. · 2012 to 2012
$378k
NIGMS NIH HHS R35 GM146957NIH HHS S10 OD011952
6 · The paper itself

Abstract

Methods for aryne difunctionalization have been the focus of recent research, but one limitation is the use of nucleophiles with proton sources. Herein, we demonstrate the use of halogen transfer reagents to enable protic amines in aryne aminohalogenation difunctionalizations in up to 86% yield. This method uses amines and arynes with a variety of N-heterocyclic scaffolds. Through a variety of derivatizations, the synthetic utility of these products is demonstrated.

Identifiers

PMID39196997
PMCPMC12032630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.