ArticleScience translational medicine2024
An autoimmune transcriptional circuit drives FOXP3
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Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed.
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing.bioRxiv : the preprint server for biology · 2026Article
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Why Is MS a More Frequent Complication of EBV Infection in Females?Immunological reviews · 2026Review
- chromIDEAS reveals epigenetic dynamics via multi-dimensional clustering of chromatin states.Nucleic acids research · 2026Article
- Peripheral immunosuppressive and immunostimulatory signatures of severity and pain in spinal cord injury.Journal of neuroinflammation · 2026Article
- T cell-mediated immunodysregulation in multiple sclerosis: from pathogenic subsets to therapeutic advances.Frontiers in immunology · 2026Review
- Beyond Foxp3 and TSDR: a dual epigenetic lock framework for treg stability and plasticity.Frontiers in immunology · 2026Review
- Host Genetic Architecture between Epstein-Barr Virus Activity and Multiple Sclerosis Reveals Shared Pathways.medRxiv : the preprint server for health sciences · 2025Article
- Peripheral nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barré syndrome.bioRxiv : the preprint server for biology · 2025Article
- Targeting Impaired Type I Interferon-IL-27 Signaling Rescues T Regulatory Cell Suppressive Function in Relapsing-Remitting Multiple Sclerosis.bioRxiv : the preprint server for biology · 2025Article
- OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.The Journal of clinical investigation · 2025Article
- Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets.Biomolecules · 2025Review
- The crosstalk between probiotics and T cell immunity.Frontiers in immunology · 2025Review
- System Xc-pathway as a potential regulatory target in neurological disorders.Frontiers in pharmacology · 2025Review
- Dynamic relationship between cerebrospinal fluid immune cells and tissue damage markers in multiple sclerosis.Brain communications · 2025Article
- Cholesterol promotesLife science alliance · 2024Article
- Immunophenotypic Profile of Adult Glioblastoma IDH-Wildtype Microenvironment: A Cohort Study.Cancers · 2024Article
- An autoimmune transcriptional circuit drives FOXP3Science translational medicine · 2024Article
- The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases.Nature reviews. Immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Tomokazu S SumidaDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-9806-2642
Matthew R LincolnDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-2962-6253
Liang HeBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-6711-2021
Yongjin ParkBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-8915-2876
Mineto OtaDepartment of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.ORCID 0000-0003-4552-8573
Akiko OguchiRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0002-9948-6295
Raku SonRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0002-9250-9474
Alice YiDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0009-0009-9715-3612
Helen A StillwellDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-2178-3473
Greta A LeissaDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-6985-9321
Keishi FujioDepartment of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.ORCID 0000-0001-7276-5254
Yasuhiro MurakawaRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0002-5415-1352
Alexander M KulminskiBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.ORCID 0000-0002-0205-8228
Charles B EpsteinBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-8358-8345
Bradley E BernsteinBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-5726-6278
Manolis KellisBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-7113-9630
David A HaflerDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-4664-535X
Funding
Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI VIJAY K. KUCHROO · 1996 to 2026
$51.7MSystems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI Albert C Shaw · 2010 to 2026
$50.4MYale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI MARCUS W BOSENBERG, Harriet M. Kluger · 2006 to 2026
$43.9MTransgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI HAFLER, DAVID A. · 2008 to 2019
$17.1MA Catalog of Cell Types and Genomic Elements in Tissues, Organoids and DiseaseUM1HG009390 · NHGRI · BROAD INSTITUTE, INC. · PI BERNSTEIN, BRADLEY EVAN · 2017 to 2021
$11.0MApoE2 and protective molecular signatures in Alzheimer's disease and agingR01AG061853 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2018 to 2022
$3.9MPersonalized genetic profiles of risk and resilience in Alzheimer's and vascular diseasesR01AG065477 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2020 to 2024
$3.8M(8) Mechanisms of autoimmune endocrine diseases in patients receiving checkpoint inhibitorsR01CA227473 · NCI · YALE UNIVERSITY · PI HEROLD, KEVAN C, KLUGER, HARRIET M. · 2018 to 2022
$3.2MGenomics of NFκB-mediated gene regulation in multiple sclerosisR01AI122220 · NIAID · YALE UNIVERSITY · PI COTSAPAS, CHRIS · 2016 to 2019
$2.9MDissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic contextR01AG070488 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M, OUKRAINTSEVA, SVETLANA V. · 2020 to 2024
$2.8MMolecular signatures of health and life span disparities between whites and African-Americans in the APOE regionR01AG047310 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2015 to 2019
$2.5MNCI NIH HHS P50 CA121974NCI NIH HHS R01 CA227473NHGRI NIH HHS UM1 HG009390NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI073748NIAID NIH HHS R01 AI122220NIAID NIH HHS U19 AI089992NIA NIH HHS R01 AG047310NIA NIH HHS R01 AG061853NIA NIH HHS R01 AG070488
Abstract
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. Although CD4
Indexed as
AutoimmunityForkhead Transcription FactorsMultiple SclerosisPositive Regulatory Domain I-Binding Factor 1T-Lymphocytes, RegulatoryAnimalsAutoimmune DiseasesChromatinHumansTranscription Factor AP-1Transcription, GeneticChromatinForkhead Transcription FactorsFOXP3 protein, humanPositive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanTranscription Factor AP-1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.