Evidence map›Paper›PMID 39196947›Full record

ArticleScience advances2024

Fluoroamphiphilic polymers exterminate multidrug-resistant Gram-negative ESKAPE pathogens while attenuating drug resistance.

Qian Zhou, Kunpeng Li, Kun Wang, Weilin Hong, Jingjie Chen, Jin Chai, Luofeng Yu, Zhangyong Si, Peng Li

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  4. Synergistic Inhibition ofMicroorganisms · 2026
    Article
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  10. CuJournal of nanobiotechnology · 2025
    Article
  11. Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers.Polymer science & technology (Washington, D.C.) · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Synthesis of New Polyfluoro Oligonucleotides via Staudinger Reaction.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qian ZhouFrontiers Science Center for Flexible Electronics, (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Ningbo Institute, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.ORCID 0009-0006-9528-5337
Kunpeng LiFrontiers Science Center for Flexible Electronics, (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Ningbo Institute, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.ORCID 0000-0003-3793-8038
Kun WangFrontiers Science Center for Flexible Electronics, (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Ningbo Institute, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.
Weilin HongFrontiers Science Center for Flexible Electronics, (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Ningbo Institute, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.
Jingjie ChenFrontiers Science Center for Flexible Electronics, (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Ningbo Institute, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.ORCID 0000-0002-4552-0144
Jin ChaiFrontiers Science Center for Flexible Electronics, (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Ningbo Institute, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.
Luofeng YuFrontiers Science Center for Flexible Electronics, (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Ningbo Institute, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.ORCID 0000-0003-2695-1800
Zhangyong SiInstitute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo Cixi Institute of Biomedical Engineering, 1219 West Zhongguan Road, Ningbo 315201, China.
Peng LiFrontiers Science Center for Flexible Electronics, (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Ningbo Institute, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.ORCID 0000-0002-5876-2177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ESKAPE pathogens are a panel of most recalcitrant bacteria that could "escape" the treatment of antibiotics and exhibit high incidence of drug resistance. The emergence of multidrug-resistant (MDR) ESKAPE pathogens (particularly Gram-negative bacteria) accounts for high risk of mortality and increased resource utilization in health care. Worse still, there has been no new class of antibiotics approved for exterminating the Gram-negative bacteria for more than 50 years. Therefore, it is urgent to develop novel antibacterial agents with low resistance and potent killing efficacy against Gram-negative ESKAPE pathogens. Herein, we present a class of fluoropolymers by mimicking the amphiphilicity of cationic antimicrobial peptides. Our optimal fluoroamphiphilic polymer (PD

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialGram-Negative BacteriaMicrobial Sensitivity TestsPolymersAnimalsGram-Negative Bacterial InfectionsHumansAnti-Bacterial AgentsPolymers

Identifiers

PMID39196947
PMCPMC11352906

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.