Evidence map›Paper›PMID 39196939›Full record

ArticleScience advances2024

Pharmacologic HIF stabilization activates costimulatory receptor expression to increase antitumor efficacy of adoptive T cell therapy.

Walter Jackson Iii, Yongkang Yang, Shaima Salman, Dominic Dordai, Yajing Lyu, Emmanuel Datan, Daiana Drehmer, Tina Yi-Ting Huang, Yousang Hwang, Gregg L Semenza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Oxygen and immunity toInfection and immunity · 2025
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Walter Jackson IiiArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2849-9697
Yongkang YangArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-0333-7712
Shaima SalmanArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2002-3117
Dominic DordaiArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0009-9015-8058
Yajing LyuArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-8253-3470
Emmanuel DatanArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Daiana DrehmerArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7329-2425
Tina Yi-Ting HuangArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Yousang HwangArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0006-1131-7777
Gregg L SemenzaArmstrong Oxygen Biology Research Center and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-0913-211X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive cell transfer (ACT) is a therapeutic strategy to augment antitumor immunity. Here, we report that ex vivo treatment of mouse CD8

Indexed as

CD8-Positive T-LymphocytesImmunotherapy, AdoptiveAmino Acids, DicarboxylicAnimalsCell Line, TumorCytotoxicity, ImmunologicGlucocorticoid-Induced TNFR-Related ProteinHypoxia-Inducible Factor 1, alpha SubunitMelanoma, ExperimentalMiceMice, Inbred C57BLReceptors, OX40Tumor Necrosis Factor Receptor Superfamily, Member 9Amino Acids, DicarboxylicGlucocorticoid-Induced TNFR-Related ProteinHypoxia-Inducible Factor 1, alpha SubunitoxalylglycineReceptors, OX40Tnfrsf18 protein, mouseTnfrsf4 protein, mouseTumor Necrosis Factor Receptor Superfamily, Member 9

Identifiers

PMID39196939
PMCPMC11817631

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.