ArticleAmerican journal of physiology. Endocrinology and metabolism2024
GCN2 drives diurnal patterns in the hepatic integrated stress response and maintains circadian rhythms in whole body metabolism during amino acid insufficiency.
Article in American journal of physiology. Endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Jordan L LevyDepartment of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, United States.ORCID 0000-0001-6494-2433
Emily T MirekDepartment of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, United States.ORCID 0000-0002-9683-8216
Esther M RodriguezDepartment of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, United States.
Maria J TolentinoDepartment of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, United States.
Brian A ZalmaDepartment of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, United States.
Troy A RoepkeDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, United States.ORCID 0000-0001-5426-2266
Ronald C WekDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Ruifeng CaoDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, United States.ORCID 0000-0001-5105-7726
Tracy G AnthonyDepartment of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, United States.ORCID 0000-0002-8586-5884
Funding
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
Homeostatic Responses to Amino Acid InsufficiencyR01DK109714 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI ANTHONY, TRACY G., WEK, RONALD C · 2016 to 2024
$5.4M
Regulation and Function of Integrated Stress ResponseR35GM136331 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI WEK, RONALD C · 2020 to 2024
$1.9M
Mammalian target of rapamycin signaling and the suprachiasmatic circadian clockR01NS118026 · NINDS · UNIVERSITY OF MINNESOTA · PI CAO, RUIFENG (RAY) · 2020 to 2024
$1.8M
Integrated stress response and the circadian clockR01GM143260 · NIGMS · UNIVERSITY OF MINNESOTA · PI CAO, RUIFENG (RAY) · 2022 to 2025
$1.4M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM143260HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM136331HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS118026HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK109714NIDDK NIH HHS R01 DK109714NIEHS NIH HHS P30 ES005022NIGMS NIH HHS R01 GM143260NIGMS NIH HHS R35 GM136331NINDS NIH HHS R01 NS118026
6 · The paper itself
Abstract
Disruptions in circadian rhythms are associated with an increased risk of developing metabolic diseases. General control nonderepressible 2 (GCN2), a primary sensor of amino acid insufficiency and activator of the integrated stress response (ISR), has emerged as a conserved regulator of the circadian clock in multiple organisms. The objective of this study was to examine diurnal patterns in hepatic ISR activation in the liver and whole body rhythms in metabolism. We hypothesized that GCN2 activation cues hepatic ISR signaling over a natural 24-h feeding-fasting cycle. To address our objective, wild-type (WT) and whole body
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
GCN2 drives diurnal patterns in the hepatic integrated stress response and maintains circadian rhythms in whole body metabolism during amino acid insufficiency. · full record | OpenQuestion