Evidence map›Paper›PMID 39196791›Full record

ArticleThe Journal of physiology2024

Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na

Andrew J Nickerson, Shaohu Sheng, Natalie A Cox, Kennedy G Szekely, Allison L Marciszyn, Tracey Lam, Jingxin Chen, Sebastien Gingras, Ossama B Kashlan, Annet Kirabo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. ENaC processing in rat kidney: effects of salt loading and ADH.American journal of physiology. Renal physiology · 2026
    Article
  2. Article
  3. Contribution of murine strain background to NabioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrew J NickersonDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7604-2344
Shaohu ShengDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-7198-1702
Natalie A CoxDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kennedy G SzekelyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Allison L MarciszynDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tracey LamDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jingxin ChenDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sebastien GingrasDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ossama B KashlanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-0537-6720
Annet KiraboDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-8580-9359
Rebecca P HugheyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Evan C RayDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2413-5415

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2008 to 2022
$13.4M
Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas R Kleyman · 2023 to 2026
$4.8M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
Renal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1M
Immune Mechanisms of Salt-Sensitive hypertensionR01HL144941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2025
$3.0M
Role of piezo channels in intercalated cellsR01DK129285 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R, SATLIN, LISA M. · 2022 to 2025
$2.3M
ENaC regulation by biliary factorsR01DK125439 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASHLAN, OSSAMA B · 2020 to 2023
$1.8M
Role of palmitoylation in regulating the epithelial sodium channel (ENAC)F32DK136356 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NICKERSON, ANDREW J · 2023 to 2023
$69k
NHLBI NIH HHS R01 HL144941NHLBI NIH HHS R01 HL147818NIDDK NIH HHS F32 DK136356NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK125439NIDDK NIH HHS R01 DK129285NIDDK NIH HHS T32 DK061296NIDDK NIH HHS U54 DK137329
6 · The paper itself

Abstract

Epithelial Na

Indexed as

Epithelial Sodium ChannelsFurinAldosteroneAnimalsColonDiet, Sodium-RestrictedMaleMiceMice, Inbred C57BLSodiumAldosteroneEpithelial Sodium ChannelsFurinSodiumaldosteroneamiloridecell biologyion channelsnephrologypatch clampproteolysisUssing chamber

Identifiers

PMID39196791
PMCPMC11384278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.