Evidence map›Paper›PMID 39196789›Full record

ArticleGenetics2024

Transformation of meiotic drive into hybrid sterility in Drosophila.

Jackson Bladen, Hyuck-Jin Nam, Nitin Phadnis

Abstract read
In one paragraph

Article in Genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. DivergenteLife · 2026
    Article
  2. Article
  3. Review
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  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jackson BladenSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Hyuck-Jin NamSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9489-6439
Nitin PhadnisSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.

Funding

University of Utah Genetics Training ProgramT32GM141848 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GOLIC, KENT G, GRUNWALD, DAVID J. · 2021 to 2025
$2.9M
The mechanisms of segregation distortion in DrosophilaR01GM141422 · NIGMS · UNIVERSITY OF UTAH · PI PHADNIS, NITIN · 2021 to 2024
$1.4M
Molecular mechanisms of genomic conflicts and hybrid incompatibilitiesR35GM156267 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Nitin Phadnis · 2025 to 2026
$847k
National Institute of Health 5T32GM141848-3NIGMS NIH HHS R01 GM141422NIGMS NIH HHS R35 GM156267NIGMS NIH HHS T32 GM141848
6 · The paper itself

Abstract

Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in the male germline. There are, however, few examples directly linking meiotic drive to hybrid sterility. In this study, we report that the Sex-Ratio chromosome of Drosophila pseudoobscura, which causes X-chromosome drive within the USA subspecies, causes near-complete male sterility when it is moved into the genetic background of the Bogota subspecies. In addition, we show that this new form of sterility is genetically distinct from the sterility of F1 hybrid males in crosses between USA males and Bogota females. Our observations provide a tractable study system where noncryptic drive within species is transformed into strong hybrid sterility between very young subspecies.

Indexed as

DrosophilaHybridization, GeneticInfertility, MaleMeiosisAnimalsFemaleMaleSex RatioX ChromosomeDrosophilagenomic conflicthybrid incompatibilitymeiotic driveSex-Ratiospeciation

Identifiers

PMID39196789
PMCPMC13031091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.