Evidence map›Paper›PMID 39196644›Full record

ArticleMolecular biology of the cell2024

The RhoGEF protein Plekhg5 self-associates via its PH domain to regulate apical cell constriction.

Ivan K Popov, Jiahui Tao, Chenbei Chang

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ivan K PopovDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.
Jiahui TaoDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.
Chenbei ChangDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Regulation of apical constriction of bottle cells by the RhoGEF protein Plekhg5 during gastrulation morphogenesisR01GM127371 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHANG, CHENBEI · 2019 to 2022
$1.5M
NCI NIH HHS P30 CA013148NIGMS NIH HHS R01 GM127371
6 · The paper itself

Abstract

RhoGEFs are critical activators of Rho family small GTPases and regulate diverse biological processes, such as cell division and tissue morphogenesis. We reported previously that the RhoGEF gene

Indexed as

Guanine Nucleotide Exchange FactorsXenopus ProteinsAnimalsCell PolarityGastrulationHumansPleckstrin Homology DomainsProtein DomainsRho Guanine Nucleotide Exchange FactorsXenopusXenopus laevisGuanine Nucleotide Exchange FactorsRho Guanine Nucleotide Exchange FactorsXenopus Proteins

Identifiers

PMID39196644
PMCPMC11481697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.