ArticleScience progress
The role of serum albumin in critical illness, predicting poor outcomes, and exploring the therapeutic potential of albumin supplementation.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Post-Sepsis Outcomes: Risk Factors for 90-Day Mortality and Infection Site-Pathogen Similarity in Recurrent Sepsis.Turkish journal of anaesthesiology and reanimation · 2026Article
- Construction and validation of a predictive nomogram for 28-day mortality in critically ill patients with toxic encephalopathy.BMC medical informatics and decision making · 2026Article
- Factors Associated with Short-Term Clinical Outcomes in ICU Patients with Carbapenem-ResistantJournal of clinical medicine · 2026Article
- Analysis of current status and risk factors of catheter infection in hemodialysis patients in Gansu Province, China.Scientific reports · 2026Article
- Development and external validation of a machine learning model for predicting the 28-day mortality risk in patients with sepsis complicated by acute respiratory failure in the ICU.Journal of intensive medicine · 2026Article
- Silent threat: how preoperative albumin levels affect geriatric cancer surgery outcomes?BMC surgery · 2026Article
- Ultrafiltration in the critically ill patient: a framework for personalized care.Critical care (London, England) · 2026Review
- Association of a dual-index phenotype and early ICU reassessment with 28-day in-hospital mortality in cardiogenic shock: a single-center observational cohort study.Frontiers in cardiovascular medicine · 2026Article
- A predictive model for central nervous system infections in children based on machine learning and clinical diagnostic features.Frontiers in pediatrics · 2026Article
- Machine Learning-Based Prediction of 28-Day Mortality in Patients with Sepsis-Induced Cardiomyopathy: An Integrated Analysis of Inflammatory Biomarkers.Journal of inflammation research · 2026Article
- Neutrophil-Percentage-to-Albumin Ratio and Monocyte-to-Albumin Ratio: Utility of the Combined Biomarkers in the Prediction of 30-Day Mortality in Male Diabetes Patients Over 80 Years Old with Bloodstream Infections.Clinical interventions in aging · 2026Article
- Construction and effect evaluation of a prediction model for malnutrition risk in patients recovering from stroke.Frontiers in nutrition · 2026Article
- ICU readmission and mortality risk prediction: Generalizability of a multi-hospital model.Journal of intensive medicine · 2025Article
- Pre-screening value of serum albumin and the glucose-lymphocyte ratio as the "transport-activation" effectors of immune checkpoint inhibitors in small cell lung cancer.Translational lung cancer research · 2025Article
- Predictive Value of IL-6 and PDGF-AA for 28-Day Mortality Risk in Critical Ill Patients.International journal of general medicine · 2025Article
- Impact of Early Administration of Albumin on Mortality Among Severe COVID-19 Patients, China.Infection and drug resistance · 2025Article
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSerum albumin (ALB) plays a vital role in maintaining oncotic pressure and contributing to hemodynamic stability, with low levels associated with adverse outcomes in critically ill patients. This study aimed to assess the association between serum ALB concentrations and poor outcomes and the possible benefits of ALB supplementation.
methodsA retrospective study involving 300 intensive care unit (ICU) patients. Albumin levels were recorded upon admission and throughout the stay, and patients were categorized based on a cutoff of 2.49 g/dl. The associations between low ALB levels and mortality were assessed using regression analysis. Additionally, it investigated the association of albumin supplementation with patient outcomes and mortality in specific patient populations.
resultsThe mean age was 54.9 years, with 68% having sepsis. Patients with low baseline ALB concentrations exhibited higher overall mortality (71% vs. 52%) and 28-day mortality (50% vs. 39%). Adjusted analyses confirmed associations with mortality. Albumin supplementation was administered to 53% of the patients. Its use demonstrated potential benefits, particularly in reducing mortality, when given to specific groups, such as sepsis and hypoalbuminemia patients. DISCUSSION: The study confirms that low serum albumin levels are strongly associated with higher mortality rates in ICU patients. Albumin supplementation showed potential benefits, particularly in patients with sepsis and low albumin levels. Further analyses explored the dosage-response relationship and identified potential groups that would benefit from albumin supplementation.
conclusionAlbumin can play a major role in predicting mortality in critically ill patients. Moreover, ALB supplementation may improve survival, especially in resource-limited settings. Future research should refine protocols through clinical trials for optimal survival in critically ill patients.
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