Evidence map›Paper›PMID 39196507›Full record

ArticleObesity surgery2024

Intestinal Energy Harvest Mediates Gut Microbiota-Associated Weight Loss Following Bariatric Surgery.

Yunzhi Qian, Alicia A Sorgen, Kristine J Steffen, Leslie J Heinberg, Kylie Reed, Ian M Carroll

Abstract read
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In one paragraph

Article in Obesity surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Reframing obesity through the gut microbiota: functional dysbiosis and metabolic disease.Current opinion in clinical nutrition and metabolic care · 2026
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yunzhi QianDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Alicia A SorgenDepartment of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, 28262, USA.
Kristine J SteffenDepartment of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, ND, 58103, USA.
Leslie J HeinbergDepartment of Psychiatry and Psychology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 44195, USA.
Kylie ReedDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Ian M CarrollDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. ian_carroll@med.unc.edu.ORCID 0000-0002-4798-4700

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
National Institute of Health 1R01DK112585-01NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

purposeMetabolic and bariatric surgery (MBS) is the most effective treatment for class III obesity. The capacity to efficiently extract intestinal energy is potentially a determinant of varying weight loss outcomes post-MBS. Prior research indicated that intestinal energy harvest is correlated with post-MBS weight loss. Studies have also demonstrated that the gut microbiota is associated with weight loss post-MBS. We aim to investigate whether gut microbiota-associated weight loss is mediated by intestinal energy harvest in patients post-MBS. MATERIALS AND

methodsWe examined the relationship between specific gut microbiota, intestinal energy harvest, diet, and weight loss using fecal metagenomic sequence data, bomb calorimetry (fecal energy content as a proxy for calorie absorption), and a validated dietary questionnaire on 67 individuals before and after MBS. Mediation analysis and a machine learning algorithm were conducted.

resultsIntestinal energy harvest was a mediator in the relationship between the intestinal microbiota (Bacteroides caccae) and weight loss outcomes in patients post-MBS at 18 months (M). The association between the abundance of B. caccae and post-MBS weight loss rate at 18 M was partly mediated by 1 M intestinal energy harvest (β = 0.001 ± 0.001, P = 0.020). This mediation represents 2.83% of the total effect (β = 0.050 ± 0.047; P = 0.028). Intestinal microbiota and energy harvest improved random forest model's accuracy in predicting weight loss results.

conclusionEnergy harvest partly mediates the relationship between the intestinal microbiota and weight loss outcomes among patients post-MBS. This study elucidates a potential mechanism regarding how intestinal energy absorption facilitates the effect of intestinal microbiota on energy metabolism and weight loss outcomes.

Indexed as

Bariatric SurgeryGastrointestinal MicrobiomeObesity, MorbidWeight LossAdultEnergy MetabolismFecesFemaleHumansMaleMiddle AgedBariatric surgeryGut microbiotaIntestinal energy harvestMediation analysisWeight loss

Identifiers

PMID39196507

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.