Evidence map›Paper›PMID 39196352›Full record

ArticleDysphagia2025

Impact of Frailty on Post-Treatment Dysphagia in Patients with Head and Neck Cancer.

Javier Hurtado-Oliva, Hans Paul van der Laan, Julius de Vries, Roel J H M Steenbakkers, Gyorgy B Halmos, Inge Wegner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dysphagia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Javier Hurtado-OlivaDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1 , PO box 30.001, Groningen, 9700RB, the Netherlands. j.a.hurtado.oliva@umcg.nl.ORCID http://orcid.org/0000-0001-7586-1671
Hans Paul van der LaanDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Julius de VriesDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1 , PO box 30.001, Groningen, 9700RB, the Netherlands.
Roel J H M SteenbakkersDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Gyorgy B HalmosDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1 , PO box 30.001, Groningen, 9700RB, the Netherlands.
Inge WegnerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1 , PO box 30.001, Groningen, 9700RB, the Netherlands.

Funding

Agencia Nacional de Investigación y Desarrollo 72210512
6 · The paper itself

Abstract

In the rising and frail head and neck cancer (HNC) population, geriatric assessments are crucial. Frail HNC patients often experience dysphagia. The coexistence of dysphagia and frailty presents complex health challenges, however, there is limited evidence on the prognostic value of frailty on post-treatment dysphagia. This study explores the relationship between pre-treatment frailty status and post-treatment dysphagia in HNC patients. A retrospective data analysis from the OncoLifeS data-biobank at the University Medical Center Groningen of 242 patients diagnosed with HNC between 2014 and 2016. The study involved several physical, functional and psychological pre-treatment geriatric assessments, and frailty screening using the Groningen Frailty Indicator (GFI) and the Geriatric-8 screening tool (G8). Outcome measures were swallowing-related quality of life (HNSW-QoL) and toxicity-related dysphagia evaluations (CTCAE-D) at 3, 6, 12 and 24 months. Linear mixed-effects models assessed factors associated with HNSW-QoL and CTCAE-D. Frail patients consistently reported worse HNSW-QoL and CTCAE-D than non-frail patients over time, with symptoms increasing at 3 months, but gradually decreasing by 24 months. Frailty status (G8 or GFI) was a significant predictor for lower HNSW-QoL (β = 11.770 and 10.936, both p < 0.001), and lower CTCAE-D (β = 0.245, p = 0.058; β = 0.331, p = 0.019), respectively. In this study, frailty was found to be associated with a worse of swallowing-related quality of life, and with increased toxicity-related dysphagia. These findings provide insights for the identification of HNC patients at higher risk of post-treatment swallowing-related issues, and offer opportunities for optimizing their post-treatment swallowing outcomes.

Indexed as

Deglutition DisordersFrailtyHead and Neck NeoplasmsAgedAged, 80 and overFemaleGeriatric AssessmentHumansMaleMiddle AgedQuality of LifeRetrospective StudiesDysphagiaFrailtyGeriatric assessmentHead and neck cancerToxicity

Identifiers

PMID39196352
PMCPMC12145293

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.