Evidence map›Paper›PMID 39196327›Full record

ArticleEuropean journal of pediatrics2024

Depression and anxiety in transgender and non-binary adolescents: prevalence and associations between adolescent and caregiver reports.

Sophia M Liles, Anna L Olsavsky, Diane Chen, Connor Grannis, Kristen R Hoskinson, Scott F Leibowitz, Eric E Nelson, Charis J Stanek, John F Strang, Leena Nahata

Abstract read
In one paragraph

Article in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophia M LilesThe Abigail Wexner Research Institute at Nationwide Children's Hospital, 431 S 18th St,, Columbus, OH, 43205, USA.ORCID http://orcid.org/0000-0003-2883-9695
Anna L OlsavskyThe Abigail Wexner Research Institute at Nationwide Children's Hospital, 431 S 18th St,, Columbus, OH, 43205, USA.ORCID http://orcid.org/0000-0001-7037-2510
Diane ChenAnn and Robert H. Lurie Children's Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-7302-9248
Connor GrannisThe Abigail Wexner Research Institute at Nationwide Children's Hospital, 431 S 18th St,, Columbus, OH, 43205, USA.ORCID http://orcid.org/0000-0001-9679-3524
Kristen R HoskinsonThe Abigail Wexner Research Institute at Nationwide Children's Hospital, 431 S 18th St,, Columbus, OH, 43205, USA.ORCID http://orcid.org/0000-0003-4044-9753
Scott F LeibowitzThe Ohio State University College of Medicine, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-9486-1415
Eric E NelsonThe Abigail Wexner Research Institute at Nationwide Children's Hospital, 431 S 18th St,, Columbus, OH, 43205, USA.ORCID http://orcid.org/0000-0002-3376-2453
Charis J StanekThe Abigail Wexner Research Institute at Nationwide Children's Hospital, 431 S 18th St,, Columbus, OH, 43205, USA.ORCID http://orcid.org/0000-0002-9937-0743
John F StrangCenter for Neuroscience, Children's National Research Institute, Children's National Hospital, Washington, DC, USA.ORCID http://orcid.org/0000-0002-0950-6177
Leena NahataThe Abigail Wexner Research Institute at Nationwide Children's Hospital, 431 S 18th St,, Columbus, OH, 43205, USA. leena.nahata@nationwidechildrens.org.ORCID http://orcid.org/0000-0003-3899-2642

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445
6 · The paper itself

Abstract

Transgender/non-binary (TNB) adolescents are at increased risk for mental health concerns, and caregiver awareness is important to facilitate access to care. Yet, limited research has examined caregiver awareness of TNB mental health. Thus, we examined (1) the prevalence of internalizing symptoms (depression, generalized anxiety, separation anxiety, social anxiety) among TNB adolescents and (2) associations between adolescent and caregiver reports of adolescent mental health symptoms. TNB adolescents (N = 75) aged 12-18 and a caregiver were recruited from a multidisciplinary gender clinic in Ohio. Adolescents self-reported their mental health symptoms via the CDI and SCARED. Caregivers reported their perceptions of the adolescent's mental health symptoms via the CASI-5. Descriptive statistics assessed participant characteristics, adolescent self-reported mental health symptoms, and caregiver proxy reports of adolescent mental health symptoms. Pearson's correlations and scatterplots were used to compare adolescent and caregiver reports and McNemar tests assessed if the differences were statistically significant. Most TNB adolescents reported elevated symptoms of depression (59%), generalized anxiety (75%), separation anxiety (52%), and social anxiety (78%). Caregiver and adolescent reports were significantly correlated for depression (r = .36, p = .002), separation anxiety (r = .39, p < .001), and social anxiety (r = .47, p < .001). Caregiver and adolescent reports of generalized anxiety were not significantly correlated (r = .21, p = .08). McNemar tests were significant (all p < .001), such that adolescents' reports met clinical cutoffs far more than their caregivers' reports.

conclusionsThough adolescent and caregiver reports were low to moderately correlated, youth reports were consistently higher, suggesting the importance of interventions to increase caregiver understanding of TNB adolescent mental health. WHAT IS KNOWN: • Transgender/non-binary adolescents are at high risk for mental health concerns and caregivers are essential to coordinate care. WHAT IS NEW: • This study expands the diagnostic mental health sub-categories examined in transgender/non-binary adolescents, noting elevated symptoms of separation and social anxiety. • Transgender/non-binary adolescents reported more symptoms of depression, generalized anxiety, separation anxiety, and social anxiety than caregivers.

Indexed as

CaregiversTransgender PersonsAdolescentAnxietyAnxiety DisordersChildCross-Sectional StudiesDepressionFemaleHumansMaleOhioPrevalenceSelf ReportCaregiver awarenessMental health symptomsTransgender

Identifiers

PMID39196327
PMCPMC11473218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.