ArticleNature cardiovascular research2024
Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias.
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Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
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27 citing papers in PubMed.
- Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- Senescence modulated cardiac repair with pluripotent stem cell-derived cardiomyocytes.Stem cell research & therapy · 2026Article
- Circumferential strain recovery after human cardiomyocyte transplantation in minipigs using a novel frequency-based method for myocardial tagging quantification.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026Article
- Electrical coupling between transplanted cardiomyocytes and host myocardium to prevent arrhythmia.Disease models & mechanisms · 2026Review
- Theoretical quantitative model and clinical outcome predictions of conductive cardiac patches for electrophysiological treatments.Nature biomedical engineering · 2026Article
- Stem Cells and Their Derivatives in Cardiac Fibrosis Therapy: Challenges and Perspectives.Cells · 2026Review
- Continuous electrocardiogram monitoring in porcine model of myocardial ischemia reperfusion.Animal models and experimental medicine · 2026Article
- Heart Regeneration for Clinical Application.Internal medicine (Tokyo, Japan) · 2026Review
- Progress and challenges in transplantation of human pluripotent stem cell derived cardiomyocytes for cardiac therapy.npj biomedical innovations · 2026Review
- CD47-mediated purification of human ventricular cardiomyocytes derived from pluripotent stem cells.Animal cells and systems · 2026Article
- Simultaneous Measurement of Contractile Force and CaSensors (Basel, Switzerland) · 2025Article
- A comprehensive review of clinical trials and Progress in stem cell therapies for advanced heart failure.Regenerative therapy · 2025Review
- Arrhythmogenic Risk in iPSC-Derived Cardiomyocytes: Current Limitations and Therapeutic Perspectives.Medicina (Kaunas, Lithuania) · 2025Review
- Optical mapping of the interface between iPSC-derived grafts and swine myocardium suggests potential arrhythmia mechanisms.NPJ Regenerative medicine · 2025Article
- Pluripotent stem cell-based approaches for heart repair and the potential of genetic modifications.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- In Vivo Targeted Reprogramming of Cardiac Fibroblasts for Heart Regeneration: Advances and Therapeutic Potential.Bioengineering (Basel, Switzerland) · 2025Review
- Exploring hiPSC-CM replacement therapy in ischemic hearts.Basic research in cardiology · 2025Review
- Recent Advances in Inflammation-Associated Epicardial Adipose Tissue for Atrial Fibrillation Patients.Reviews in cardiovascular medicine · 2025Review
- Differential impact of substrates on myosin heavy and light chain expression in human stem cell-derived cardiomyocytes at single-cell level.Journal of muscle research and cell motility · 2025Article
- Enhancing human pluripotent stem cell differentiation to cardiomyocytes through cardiac progenitor reseeding and cryopreservation.iScience · 2025Article
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Authors and funding
43 authors.
Dinesh Selvakumar *Centre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Zoe E Clayton *Centre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Andrew ProwseAustralian Institute for Bioengineering and Nanotechnology, the University of Queensland, St Lucia, Queensland, Australia.
Steve DingwallAustralian Institute for Bioengineering and Nanotechnology, the University of Queensland, St Lucia, Queensland, Australia.
Sul Ki KimCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Leila ReyesCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Jacob GeorgeCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Haisam ShahCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Siqi ChenCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.ORCID 0000-0003-1982-3974
Halina H L LeungCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Robert D HumeCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Laurentius TjahjadiCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Sindhu IgoorCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Rhys J P SkeltonCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Alfred HingDepartment of Cardiothoracic Surgery, Westmead Hospital, Westmead, New South Wales, Australia.
Hugh PatersonSydney Imaging, Core Research Facility, the University of Sydney, Sydney, New South Wales, Australia.
Sheryl L FosterDepartment of Radiology, Westmead Hospital, Westmead, New South Wales, Australia.ORCID 0000-0003-3725-0823
Lachlan PearsonCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Emma WilkieCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.
Alan D MarcusCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.ORCID 0000-0002-5013-9751
Prajith JeyaprakashDepartment of Cardiology, Nepean Hospital, Kingswood, New South Wales, Australia.
Zhixuan WuInstitute for Molecular Bioscience, the University of Queensland, St Lucia, Queensland, Australia.
Han Shen ChiuInstitute for Molecular Bioscience, the University of Queensland, St Lucia, Queensland, Australia.
Cherica Felize J OngtengcoAustralian Institute for Bioengineering and Nanotechnology, the University of Queensland, St Lucia, Queensland, Australia.
Onkar MulayGenomics and Machine Learning Lab, Division of Genetics and Genomics, Institute for Molecular Bioscience, the University of Queensland, St Lucia, Queensland, Australia.
Jeffrey R McArthurVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Tony BarryDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.
Juntang LuDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.
Vu TranDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.
Richard BennettDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.
Yasuhito KotakeDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.
Timothy CampbellDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.ORCID 0000-0003-4793-7741
Samual TurnbullDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.ORCID 0000-0002-6328-6689
Anunay GuptaDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.
Quan NguyenGenomics and Machine Learning Lab, Division of Genetics and Genomics, Institute for Molecular Bioscience, the University of Queensland, St Lucia, Queensland, Australia.ORCID 0000-0001-7870-5703
Guiyan NiGenomics and Machine Learning Lab, Division of Genetics and Genomics, Institute for Molecular Bioscience, the University of Queensland, St Lucia, Queensland, Australia.
Stuart M GrieveImaging and Phenotyping Laboratory, Faculty of Medicine and Health, Charles Perkins Centre, the University of Sydney, Sydney, New South Wales, Australia.
Nathan J PalpantInstitute for Molecular Bioscience, the University of Queensland, St Lucia, Queensland, Australia.ORCID 0000-0002-9334-8107
Faraz PathanDepartment of Cardiology, Nepean Hospital, Kingswood, New South Wales, Australia.
Eddy KizanaCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia.ORCID 0000-0002-7266-6720
Saurabh KumarDepartment of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.
Peter P GrayAustralian Institute for Bioengineering and Nanotechnology, the University of Queensland, St Lucia, Queensland, Australia.
James J H ChongCentre for Heart Research, the Westmead Institute for Medical Research, the University of Sydney, Westmead, New South Wales, Australia. james.chong@sydney.edu.au.ORCID 0000-0002-5201-4856
Funding
Department of Health | National Health and Medical Research Council (NHMRC) APP1194139/APP1126276National Heart Foundation of Australia (Heart Foundation) 101889
Abstract
Preclinical data have confirmed that human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) can remuscularize the injured or diseased heart, with several clinical trials now in planning or recruitment stages. However, because ventricular arrhythmias represent a complication following engraftment of intramyocardially injected PSC-CMs, it is necessary to provide treatment strategies to control or prevent engraftment arrhythmias (EAs). Here, we show in a porcine model of myocardial infarction and PSC-CM transplantation that EAs are mechanistically linked to cellular heterogeneity in the input PSC-CM and resultant graft. Specifically, we identify atrial and pacemaker-like cardiomyocytes as culprit arrhythmogenic subpopulations. Two unique surface marker signatures, signal regulatory protein α (SIRPA)
Indexed as
Arrhythmias, CardiacMyocytes, CardiacAction PotentialsAnimalsAnti-Arrhythmia AgentsBiomarkersCell DifferentiationCells, CulturedDisease Models, AnimalHeart RateHumansInduced Pluripotent Stem CellsMyocardial InfarctionPhenotypePluripotent Stem CellsStem Cell TransplantationAnti-Arrhythmia AgentsBiomarkers
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.