ArticleNature cardiovascular research2022
Triggering of myocardial infarction by heat exposure is modified by medication intake.
Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Research opportunities to advance cardiovascular health through a planetary health lens.American journal of preventive cardiology · 2026Review
- The Impact of Ambient Temperature on the Cardiovascular and Cerebrovascular Disease Incidence during 2009-2023 in Zhanjiang, Guangdong, China.Journal of atherosclerosis and thrombosis · 2026Article
- Non optimal temperatures and chronic cardiovascular diseases.Seminars in immunopathology · 2026Review
- Ischemic heart disease burden and healthcare system readiness across sub-Saharan Africa.Nature cardiovascular research · 2026Review
- Impact of seasonal temperature variations on adverse outcomes in atrial fibrillation: comparative insights from Vigo and Murcia cohorts.Journal of global health · 2026Article
- Effect of Air Pollution Reductions on Mortality During the COVID-19 Lockdowns in Early 2020.Research report (Health Effects Institute) · 2025Article
- Air pollution and serious bleeding events in high-risk older adults.Environmental research · 2024Article
- Heat Exposure and Cause-Specific Hospital Admissions in Spain: A Nationwide Cross-Sectional Study.Environmental health perspectives · 2024Article
- Environmental Impacts on Cardiovascular Health and Biology: An Overview.Circulation research · 2024Review
- Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries.JAMA network open · 2024Article
- Racial/ethnic disparities in PMNature human behaviour · 2023Article
- Ambient temperature and seasonal variation in inpatient mortality from respiratory diseases: a retrospective observational study.The Lancet regional health. Europe · 2023Article
- Heat in Germany: Health risks and preventive measures.Journal of health monitoring · 2023Article
- Diabetes and climate change: current evidence and implications for people with diabetes, clinicians and policy stakeholders.Diabetologia · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute myocardial infarction (MI) can be triggered by heat exposure, but it remains unknown whether patients taking certain cardiovascular medications have elevated vulnerability. Based on a validated and complete registration of all 2,494 MI cases in Augsburg, Germany, during warm seasons (May to September) from 2001 to 2014, here we show that heat-related non-fatal MI risk was elevated among users of anti-platelet medication and beta-receptor blockers, respectively, but not among non-users, with significant differences between users and non-users. We also found that these effect modifications were stronger among younger patients (25-59 years), who had a lower prevalence of pre-existing coronary heart disease (CHD, a potential confounder by indication), than among older patients (60-74 years), who had a higher prevalence of pre-existing CHD. Users of these medications may be more vulnerable than non-users to non-fatal MI risk due to heat exposure. Further research is needed to disentangle effect modification by medication use from effect modification by pre-existing CHD.
Identifiers
39196082What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.