ArticleNature cardiovascular research2023
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice.
Abstract read
In one paragraph
Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Macrophage-associated kinase signaling in atherosclerosis - a systematic review.Cell communication and signaling : CCS · 2026Pooled it
- Early atherogenesis: In search of etiology.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- The N-terminus of apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells.The Journal of clinical investigation · 2026Article
- Triglyceride-Rich Lipoprotein Metabolism and Cardiovascular Risk in Diabetes: Bedside to Bench to Bedside.Circulation research · 2026Review
- ABCA1-Mediated Structural Diversity of HDL Subspecies and Their Proposed Roles in Cardioprotection.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Cell type-specific contribution of low-density lipoprotein receptor to atherosclerosis.Science China. Life sciences · 2026Article
- Endothelial Cell Regulation of Lipid Uptake During Feeding and Fasting.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Non-remnant triglyceride-rich lipoproteins due to lipoprotein lipase deficiency increase atherosclerosis in mice.Nature communications · 2026Article
- Tigloylgomisin P Inhibits Endothelial Inflammation by Regulating the NF-κB and Smad1/5/9 Pathways.Journal of lipid and atherosclerosis · 2026Article
- Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations.Nature communications · 2025Article
- Bone morphogenetic protein (BMP)-9, a systemic homeostasis factor with diverse functions in the liver and beyond.Bioscience reports · 2025Review
- Lipid raft proteomics identify endothelial myosin-9 (MYH9) as a regulator of low-density lipoprotein transcytosis and atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Aged human serum induces vascular changes in an isogenic co-culture venule model.Stem cell reports · 2025Article
- Bone morphogenetic protein-9 controls pulmonary vascular growth and remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genotype-Phenotype Relationship in Hereditary Hemorrhagic Telangiectasia: Quality of Life and Cardiovascular Risk Evaluation.Journal of clinical medicine · 2025Article
- Inflammation in atherosclerosis: a Big Idea that has underperformed so far.Current opinion in lipidology · 2025Review
- Transcytosis of LDL Across Arterial Endothelium: Mechanisms and Therapeutic Targets.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Metaboloepigenetics: Role in the Regulation of Flow-Mediated Endothelial (Dys)Function and Atherosclerosis.Cells · 2025Review
- Hereditary haemorrhagic telangiectasia.Nature reviews. Disease primers · 2025Review
- Atherosclerosis: from lipid-lowering and anti-inflammatory therapies to targeting arterial retention of ApoB-containing lipoproteins.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Sungwoon LeeDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Hubertus SchleerGenovac Antibody Discovery, Fargo, ND, USA.
Hyojin ParkDepartment of Internal Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA.
Erika JangDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Michael BoyerDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Bo TaoDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Ana Gamez-MendezDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0638-9988
Abhishek SinghDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Ewa Folta-StogniewW.M. Keck Biotechnology Resource Laboratory, Yale University School of Medicine, New Haven, CT, USA.
Xinbo ZhangVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9184-5767
Lingfeng QinVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.
Xue XiaoQuantitative Biomedical Research Center, Department of Population & Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lin XuQuantitative Biomedical Research Center, Department of Population & Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-5815-4457
Junhui ZhangDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Xiaoyue HuYale Cardiovascular Research Center, Department of Internal Medicine, Yale University, School of Medicine, New Haven, CT, USA.
Evanthia PashosInternal Medicine Research, Unit Pfizer Inc., Cambridge, MA, USA.
George TellidesDepartment of Surgery, Yale University School of Medicine, New Haven, CT, USA.
Philip W ShaulCenter for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1157-4002
Warren L LeeDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-1788-6587
Carlos Fernandez-HernandoVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3950-1924
Anne EichmannDepartment of Internal Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA.
William C SessaDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA. William.sessa@yale.edu.ORCID 0000-0001-5759-1938
Funding
Insights into the Molecular and Cellular Mechanisms governing Endothelial FunctionR35HL139945 · NHLBI · YALE UNIVERSITY · PI SESSA, WILLIAM C · 2018 to 2021
$4.3MNHLBI NIH HHS R35 HL139945
Abstract
Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis initiation and progression
Indexed as
Activin Receptors, Type IIAtherosclerosisEndothelial CellsLipoproteins, LDLReceptors, LDLTranscytosisAnimalsCells, CulturedDiet, High-FatDisease Models, AnimalGrowth Differentiation Factor 2HumansMacrophagesMaleMiceMice, Inbred C57BLActivin Receptors, Type IIAcvrl1 protein, mouseGrowth Differentiation Factor 2Lipoproteins, LDLReceptors, LDL
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.