Evidence map›Paper›PMID 39196043›Full record

ArticleNature cardiovascular research2023

Three-dimensional morphologic and molecular atlases of nasal vasculature.

Seon Pyo Hong, Myung Jin Yang, Jung Hyun Bae, Du Ri Choi, Young-Chan Kim, Myeon-Sik Yang, Byungkwan Oh, Kyung Won Kang, Sang-Myeong Lee, Bumseok Kim and 3 more

Erratum issuedAbstract read
In one paragraph

Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Olfactory immunity: defending the neural-mucosal barrier.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Seon Pyo HongCenter for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.ORCID 0000-0002-9923-8099
Myung Jin YangCenter for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.ORCID 0000-0003-4493-9418
Jung Hyun BaeCenter for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.
Du Ri ChoiCenter for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.ORCID 0000-0002-0174-8307
Young-Chan KimCenter for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.ORCID 0000-0002-6726-5957
Myeon-Sik YangLaboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea.ORCID 0000-0003-1858-3729
Byungkwan OhLaboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea.ORCID 0000-0001-6540-8945
Kyung Won KangDivision of Biotechnology, College of Environmental and Bioresources, Jeonbuk National University, Iksan, Republic of Korea.
Sang-Myeong LeeLaboratory of Veterinary Virology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Bumseok KimLaboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea.ORCID 0000-0003-0392-2513
Yong-Dae KimDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Yeungnam University, Daegu, Republic of Korea.
Ji Hoon AhnCenter for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea. ahnadun@kaist.ac.kr.ORCID 0000-0002-0122-3105
Gou Young KohCenter for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea. gykoh@kaist.ac.kr.ORCID 0000-0002-1231-1485

Funding

Institute for Basic Science (IBS) IBS-R025-D1-2015
6 · The paper itself

Abstract

Understanding the function of the nasal vasculature in homeostasis and pathogenesis of common nasal diseases is important. Here we describe an extensive network of venous sinusoids (VSs) in mouse and human nasal mucosa. The endothelium of the VSs expressed Prox1 (considered to be a constitutive marker of lymphatic endothelium) and high levels of VCAM-1 and exhibited unusual cell-to-cell junctions. VSs are supported by circular smooth muscle cells (SMCs) and surrounded by immune cells. The nasal mucosa also showed a rich supply of lymphatic vessels with distinctive features, such as the absence of the lymphatic marker LYVE1 and sharp-ended capillaries. In mouse models of allergic rhinitis or acute Coronavirus Disease 2019 (COVID-19) infection, Prox1

Indexed as

COVID-19Nasal MucosaAnimalsDisease Models, AnimalFemaleHomeodomain ProteinsHumansImaging, Three-DimensionalLymphatic VesselsMaleMiceMice, Inbred C57BLMyocytes, Smooth MuscleProspero-Related Homeobox 1 ProteinRhinitis, AllergicSARS-CoV-2Homeodomain ProteinsProspero-Related Homeobox 1 ProteinTumor Suppressor ProteinsVascular Cell Adhesion Molecule-1

Identifiers

PMID39196043
PMCPMC11358012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.