Evidence map›Paper›PMID 39196037›Full record

ArticleNature cardiovascular research2024

Titin truncating variants, cardiovascular risk factors and the risk of atrial fibrillation and heart failure.

Naman S Shetty, Mokshad Gaonkar, Akhil Pampana, Nirav Patel, Peng Li, Garima Arora, Pankaj Arora

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naman S ShettyDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mokshad GaonkarDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Akhil PampanaDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-4167-0540
Nirav PatelDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Peng LiSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-9026-9999
Garima AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Pankaj AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA. parora@uabmc.edu.ORCID http://orcid.org/0000-0003-2420-3550

Funding

Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood PressureR01HL160982 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.7M
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological StudyR01HL163081 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.7M
The Effects of Neprilysin Inhibition on Cardiometabolic Health in Black IndividualsR01HL163852 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.6M
Race, Natriuretic Peptides and Physiological PerturbationsK23HL146887 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ARORA, PANKAJ · 2019 to 2023
$969k
U.S. Department of Health & Human Services | National Institutes of Health (NIH) K23HL146887U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL160982U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL163081U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL163852
6 · The paper itself

Abstract

High-proportion spliced-in (hiPSI) titin truncating variant (TTNtv) carriers have a higher risk of atrial fibrillation and heart failure

Indexed as

Atrial FibrillationConnectinHeart Disease Risk FactorsHeart FailureFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPhenotypePrognosisRisk AssessmentRisk FactorsUnited KingdomConnectinTTN protein, human

Identifiers

PMID39196037

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.