ArticleNature cardiovascular research2024
Myocardial ultrastructure of human heart failure with preserved ejection fraction.
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Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Patients with asymptomatic severe mitral regurgitation already have abnormal left ventricular myocardial sarcomeric ultrastructural characteristics.JTCVS open · 2026Article
- Review
- Integrated Myocardial and Plasma Lipidome Across the Human Obesity-Heart Failure Spectrum.Research square · 2026Article
- Single-Cell Analysis of Human Heart Failure With Preserved Ejection Fraction.Circulation research · 2026Article
- Cardiac Lipid Metabolism: Cells, Metabolites, and Rhythms.Circulation research · 2026Review
- Severe obesity in human HFpEF alters contractile protein function and organization.Science (New York, N.Y.) · 2026Article
- Consensus statement on mass spectrometry-based proteomic analysis of cardiac tissue.Nature cardiovascular research · 2026Article
- Inflammation, metabolism, and aging in heart failure with preserved ejection fraction: Mechanisms and treatment perspectives.Journal of translational internal medicine · 2026Article
- Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.Apoptosis : an international journal on programmed cell death · 2026Review
- Regulatory mechanisms and interactions of mitophagy and ketone body metabolism in cardiac metabolism.Frontiers in cardiovascular medicine · 2026Review
- Pathophysiology of HFpEF: Insights from a Metabolic-Mitochondrial Perspective.International journal of molecular sciences · 2025Review
- Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures.bioRxiv : the preprint server for biology · 2025Article
- Systemic Interactions in HFpEF: A Multiorgan Perspective on Pathways and Therapeutic Targets.Journal of cardiovascular translational research · 2025Review
- Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.Nature cardiovascular research · 2025Article
- Review
- Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025Review
- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- Quantitative proteomics of formalin-fixed, paraffin-embedded cardiac specimens uncovers protein signatures of specialized regions and patient groups.Nature cardiovascular research · 2025Article
- Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss.bioRxiv : the preprint server for biology · 2025Article
- Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Mariam MeddebDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6922-1587
Navid KoleiniDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Aleksandra BinekAdvanced Clinical Biosystems Research Institute, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mohammad KeykhaeiDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5728-7848
Reyhane DarehgazaniDepartment of Biological Sciences, University of Maryland, Baltimore, MD, USA.
Seoyoung KwonDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Celia AboafDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kenneth B MarguliesCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8093-4465
Ken C BediCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3588-9324
Mohamed LeharDepartment of Anesthesia, Johns Hopkins University, Baltimore, MD, USA.
Kavita SharmaDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Virginia S HahnDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-0578-2668
Jennifer E Van EykAdvanced Clinical Biosystems Research Institute, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cinthia I DrachenbergDepartment of Pathology, University of Maryland, Baltimore, MD, USA. cdrachenberg@som.umaryland.edu.ORCID http://orcid.org/0000-0002-3104-5661
David A KassDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. dkass@jhmi.edu.ORCID http://orcid.org/0000-0003-1596-2299
Funding
PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2MLeveraging Protein Kinase G-1 Nanodomain Control and Molecular Targeting to Enhance its Therapeutic Use Against Myocardial DiseaseR35HL135827 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2017 to 2023
$6.3MMechanical Stress-Dependent Remodeling of the Cardiac Microtubule NetworkR01HL149891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Kenneth Ber Margulies, Benjamin Lears Prosser · 2020 to 2026
$4.2MIntersection of Obesity and Heart Failure with Preserved Ejection FractionR35HL166565 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI David Alan Kass · 2023 to 2026
$4.1MExosome Therapeutics to Dissect HFpEF MechanismsR01HL155346 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI MARBAN, EDUARDO, VAN EYK, JENNIFER E · 2021 to 2024
$3.3MPhosphorylation of TSC2 (S1365) as a novel Regulator of mTORC1 Signaling in T CellsR01AI156274 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PEARCE, ERIKA L · 2021 to 2025
$2.6MAnalysis of Single Cell Transcriptomics and Cardiac Metabolism in Heart Failure with Preserved Ejection FractionK23HL166770 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Virginia Shalkey Hahn · 2023 to 2026
$792kAmerican Heart Association (American Heart Association, Inc.) 16SFRN28620000American Heart Association (American Heart Association, Inc.) 20SRG35490443American Heart Association (American Heart Association, Inc.) 23POST1026402NHLBI NIH HHS K23 HL166770NHLBI NIH HHS L30 HL138884NHLBI NIH HHS R01 HL149891NHLBI NIH HHS R01 HL155346NHLBI NIH HHS R35 HL135827NHLBI NIH HHS R35 HL166565NHLBI NIH HHS T32 HL007227NIAID NIH HHS R01 AI156274U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL007227U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL135827U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL149891U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL155346U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL166565U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL166565-01U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K23HL166770
Abstract
Over half of patients with heart failure have a preserved ejection fraction (>50%, called HFpEF), a syndrome with substantial morbidity/mortality and few effective therapies
Indexed as
Heart FailureMitochondria, HeartMyocardiumStroke VolumeAgedBiopsyComorbidityFemaleHumansLipid DropletsMaleMicroscopy, Electron, TransmissionMiddle AgedObesityProteomicsSarcomeres
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