Evidence map›Paper›PMID 39195997›Full record

ArticleNature cardiovascular research2023

Excess cardiovascular mortality across multiple COVID-19 waves in the United States from March 2020 to March 2022.

Lefei Han, Shi Zhao, Siyuan Li, Siyu Gu, Xiaobei Deng, Lin Yang, Jinjun Ran

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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  17. Impact of COVID-19 Pandemic on Treatment and Outcome of Patients With Femoropopliteal Peripheral Arterial Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lefei Han *School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-3254-9527
Shi Zhao *JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong SAR, China.
Siyuan Li *School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Siyu GuSchool of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaobei DengSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lin YangSchool of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China. l.yang@polyu.edu.hk.ORCID 0000-0002-5964-3233
Jinjun RanSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jinjunr@sjtu.edu.cn.ORCID 0000-0002-2684-6341

Funding

Shanghai Science and Technology Development Foundation (Shanghai Science and Technology Development Fund) 22YF1421100
6 · The paper itself

Abstract

The COVID-19 pandemic has limited the access of patients with cardiovascular diseases to healthcare services, causing excess deaths. However, a detailed analysis of temporal variations of excess cardiovascular mortality during the COVID-19 pandemic has been lacking. Here we estimate time-varied excess cardiovascular deaths (observed deaths versus expected deaths predicted by the negative binomial log-linear regression model) in the United States. From March 2020 to March 2022 there were 90,160 excess cardiovascular deaths, or 4.9% more cardiovascular deaths than expected. Two large peaks of national excess cardiovascular mortality were observed during the periods of March-June 2020 and June-November 2021, coinciding with two peaks of COVID-19 deaths, but the temporal patterns varied by state, age, sex and race and ethnicity. The excess cardiovascular death percentages were 5.7% and 4.0% in men and women, respectively, and 3.6%, 8.8%, 7.5% and 7.7% in non-Hispanic White, Black, Asian and Hispanic people, respectively. Our data highlight an urgent need for healthcare services optimization for patients with cardiovascular diseases in the COVID-19 era.

Indexed as

Cardiovascular DiseasesCOVID-19AdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPandemicsSARS-CoV-2United StatesYoung Adult

Identifiers

PMID39195997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.