Evidence map›Paper›PMID 39195979›Full record

ArticleNature cardiovascular research2022

Kir2.1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen-Tawil syndrome type 1.

Álvaro Macías, Andrés González-Guerra, Ana I Moreno-Manuel, Francisco M Cruz, Lilian K Gutiérrez, Nieves García-Quintáns, Marta Roche-Molina, Francisco Bermúdez-Jiménez, Vicente Andrés, María Linarejos Vera-Pedrosa and 3 more

Abstract read
In one paragraph

Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. MOG1medRxiv : the preprint server for health sciences · 2025
    Article
  4. Potassium-sensitive loss of muscle force in the setting of reduced inward rectifier KProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. The network of cardiac KNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  9. Article
  10. Extracellular Kir2.1Circulation research · 2024
    Article
  11. Extracellular cysteine disulfide bond break at Cys122 disrupts PIPbioRxiv : the preprint server for biology · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Álvaro MacíasCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-9952-6947
Andrés González-Guerra *Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID http://orcid.org/0000-0003-1230-5293
Ana I Moreno-Manuel *Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-5011-2786
Francisco M CruzCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Lilian K GutiérrezCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Nieves García-QuintánsCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Marta Roche-MolinaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Francisco Bermúdez-JiménezCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Vicente AndrésCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-0125-7209
María Linarejos Vera-PedrosaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Isabel Martínez-CarrascosoCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Juan A BernalCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. juanantonio.bernal@cnic.es.
José JalifeCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. jjalife@cnic.es.ORCID http://orcid.org/0000-0003-0080-3500

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) GA-965286Fundació la Marató de TV3 (TV3 Marathon Foundation) 736/C/2020Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI20/01220
6 · The paper itself

Abstract

Andersen-Tawil syndrome type 1 (ATS1) is associated with life-threatening arrhythmias of unknown mechanism. In this study, we generated and characterized a mouse model of ATS1 carrying the trafficking-deficient mutant Kir2.1

Identifiers

PMID39195979
PMCPMC11358039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.