ArticleNature cardiovascular research2022
Pseudodynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left-right asymmetry.
Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Following your heart as it takes shape.eLife · 2026Article
- Article
- Spatiotemporal gene expression and cellular dynamics of the developing human heart.Nature genetics · 2025Article
- Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors.Developmental biology · 2025Article
- A method for analysing tissue motion and deformation during mammalian organogenesis.PLoS computational biology · 2025Article
- Clipping spline: interactive, dynamic 4D volume clipping and analysis based on thin plate spline.Biomedical optics express · 2025Article
- morphoHeart: A quantitative tool for integrated 3D morphometric analyses of heart and ECM during embryonic development.PLoS biology · 2025Article
- Single-cell morphometrics reveals T-box gene-dependent patterns of epithelial tension in the Second Heart field.Nature communications · 2024Article
- Early heart development: examining the dynamics of function-form emergence.Biochemical Society transactions · 2024Review
- ProDiVis: a method to normalize fluorescence signal localization in 3D specimens.Frontiers in cell and developmental biology · 2024Article
- Imaging Approaches and the Quantitative Analysis of Heart Development.Journal of cardiovascular development and disease · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Understanding organ morphogenesis requires a precise geometrical description of the tissues involved in the process. The high morphological variability in mammalian embryos hinders the quantitative analysis of organogenesis. In particular, the study of early heart development in mammals remains a challenging problem due to imaging limitations and complexity. Here, we provide a complete morphological description of mammalian heart tube formation based on detailed imaging of a temporally dense collection of mouse embryonic hearts. We develop strategies for morphometric staging and quantification of local morphological variations between specimens. We identify hot spots of regionalized variability and identify Nodal-controlled left-right asymmetry of the inflow tracts as the earliest signs of organ left-right asymmetry in the mammalian embryo. Finally, we generate a three-dimensional+t digital model that allows co-representation of data from different sources and provides a framework for the computer modeling of heart tube formation.
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Registered trials
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