Evidence map›Paper›PMID 39195931›Full record

ArticleNature cardiovascular research2024

Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion.

Ali A Tuz, Susmita Ghosh, Laura Karsch, Dimitris Ttoouli, Sai P Sata, Özgür Ulusoy, Andreas Kraus, Nils Hoerenbaum, Jan-Niklas Wolf, Sabrina Lohmann and 41 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  15. Predictive Value of IBI for In-Hospital Death in Elderly Patients with Non-ST-Segment Elevation Myocardial Infarction.Medical science monitor : international medical journal of experimental and clinical research · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

51 authors.

Ali A TuzInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Susmita GhoshLeibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany.
Laura KarschInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Dimitris TtoouliBioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany.
Sai P SataLeibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany.
Özgür UlusoyInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Andreas KrausInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Nils HoerenbaumInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Jan-Niklas WolfInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Sabrina LohmannInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Franziska ZwirnleinInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Viola KaygusuzInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Vivian LakovicInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Hannah-Lea TummesInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Alexander BeerInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Markus GallertInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Stephanie ThiebesDepartment of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital Essen, Essen, Germany.ORCID 0000-0001-5320-3889
Altea QefaliaInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Zülal CibirInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Medina AntlerInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Sebastian KorsteDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany.
Elias Haj YehiaDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany.
Lars MichelDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany.
Tienush RassafDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany.
Britta KaltwasserDepartment of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany.
Hossam AbdelrahmanInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Ayan Mohamud YusufDepartment of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany.
Chen WangDepartment of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany.
Dongpei YinDepartment of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany.
Lars HaeuslerInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Smiths LueongDivision of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Mathis RichterInstitute for Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), Universität Münster, Münster, Germany.ORCID 0000-0002-3110-6137
Daniel R EngelDepartment of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital Essen, Essen, Germany.ORCID 0000-0001-7301-353X
Martin StenzelLeibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany.ORCID 0000-0002-1378-2529
Oliver SoehnleinInstitute for Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), Universität Münster, Münster, Germany.ORCID 0000-0002-7854-0694
Benedikt FrankDepartment of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany.
Mialitiana Solo-NomenjanaharyOptimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, U1144 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Benoît Ho-Tin-NoéOptimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, U1144 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.ORCID 0000-0002-7428-1760
Jens T SivekeDivision of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias TotzeckDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany.
Daniel HoffmannBioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-2973-7869
Anika GrüneboomLeibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany.ORCID 0000-0002-7928-5613
Nina HagemannDepartment of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany.
Anja HasenbergInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.
Jean-Philippe DesillesOptimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, U1144 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Mikael MazighiOptimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, U1144 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Albert SickmannLeibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany.
Jianxu ChenLeibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany.ORCID 0000-0002-8500-1357
Dirk M HermannDepartment of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-0198-3152
Matthias GunzerInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany. matthias.gunzer@uk-essen.de.ORCID 0000-0002-5534-6055
Vikramjeet SinghInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany. vikramjeet.singh@uk-essen.de.ORCID 0000-0002-7361-8317

Funding

The molecular basis of gustatory coding in DrosophilaF31DC007559 · NIDCD · YALE UNIVERSITY · PI PERRY, JENNIFER J · 2005 to 2006
$84k
Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie (Federal Ministry for Education, Science, Research and Technology) 161L0272Deutsche Forschungsgemeinschaft (German Research Foundation) 3173/12-1, 3173/13-1Deutsche Forschungsgemeinschaft (German Research Foundation) 3173/15-1Deutsche Forschungsgemeinschaft (German Research Foundation) GU769/10-1Deutsche Forschungsgemeinschaft (German Research Foundation) HE3173/11-1Deutsche Forschungsgemeinschaft (German Research Foundation) SI 2650/1-1NIDCD NIH HHS F31 DC007559
6 · The paper itself

Abstract

Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer's patches (PP) and lamina propria. Here we show that patients with stroke and myocardial ischemia (MI) had strongly reduced IgA blood levels. This was phenocopied in experimental mouse models where decreased plasma and fecal IgA were accompanied by rapid loss of IgA-producing plasma cells in PP and lamina propria. Reduced plasma IgG was detectable in patients and experimental mice 3-10 d after injury. Stroke/MI triggered the release of neutrophil extracellular traps (NETs). Depletion of neutrophils, NET degradation or blockade of NET release inhibited the loss of IgA

Indexed as

Extracellular TrapsMyocardial InfarctionNeutrophilsAgedAnimalsCase-Control StudiesDisease Models, AnimalFemaleHumansImmunity, HumoralImmunoglobulin AImmunoglobulin GMaleMiceMice, Inbred C57BLMiddle AgedImmunoglobulin AImmunoglobulin G

Identifiers

PMID39195931
PMCPMC11358010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.