Evidence map›Paper›PMID 39195512›Full record

ArticleMetabolites2024

Lipidomics by Nuclear Magnetic Resonance Spectroscopy and Liquid Chromatography-High-Resolution Mass Spectrometry in Osteosarcoma: A Pilot Study.

João Guilherme de Moraes Pontes, Milka Jadranin, Márcia Regina Assalin, Melissa Quintero Escobar, Danijela Stanisic, Tássia Brena Barroso Carneiro Costa, André van Helvoort Lengert, Érica Boldrini, Sandra Regina Morini da Silva, Daniel Onofre Vidal and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

João Guilherme de Moraes PontesLaboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.ORCID 0000-0002-9369-7809
Milka JadraninLaboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.ORCID 0000-0002-4235-3504
Márcia Regina AssalinLaboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
Melissa Quintero EscobarLaboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.ORCID 0000-0002-2645-7418
Danijela StanisicLaboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
Tássia Brena Barroso Carneiro CostaLaboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.ORCID 0000-0001-5028-5815
André van Helvoort LengertMolecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos 14784-400, Brazil.ORCID 0000-0002-3632-343X
Érica BoldriniBarretos Children's Cancer Hospital, Barretos 14784-400, Brazil.
Sandra Regina Morini da SilvaDepartment of Pathology, Barretos Cancer Hospital, Barretos 14784-400, Brazil.
Daniel Onofre VidalMolecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos 14784-400, Brazil.ORCID 0000-0003-2117-3640
Leticia Huan Bacellar LiuLaboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
Mariana MaschiettoBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas 13083-100, Brazil.ORCID 0000-0003-2589-3186
Ljubica TasicLaboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.ORCID 0000-0003-2930-7332

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Finance Code 001International Cooperation Branch, Organisation for the Prohibition of Chemical Weapons (OPCW) L/ICA/ICB/221146/19Sao Paulo Research Foundation #2018/06510-4, #2018/21047-9, 2018/24069-3, 2014250-7), post-doctorate fellowship (#2023/03780-9, JGMP)
6 · The paper itself

Abstract

Cancer is a complex disease that can also affect the younger population; however, it is responsible for a relatively high mortality rate of children and youth, especially in low- and middle-income countries (LMICs). Besides that, lipidomic studies in this age range are scarce. Therefore, we analyzed blood serum samples from young patients (12 to 35 years) with bone sarcoma (osteosarcoma) and compared their lipidomics to the ones from the control group of samples, named healthy control (HC group), using NMR and LC-MS techniques. Furthermore, differences in the lipidomic profiles between OS patients with and without metastasis indicate higher glycerophosphocholine (GPC) and glycerophospholipid (GPL) levels in osteosarcoma and increased cholesterol, choline, polyunsaturated fatty acids (PUFAs), and glycerols during the metastasis. These differences, detected in the peripheral blood, could be used as biomarkers for liquid biopsy.

Indexed as

bone tumormass spectrometrymetastasisnuclear magnetic resonance spectroscopyosteosarcoma

Identifiers

PMID39195512
PMCPMC11356186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.