Evidence map›Paper›PMID 39195508›Full record

ReviewMetabolites2024

Metabolic Pathways in Hydrocephalus: Profiling with Proteomics and Advanced Imaging.

Laura May Davis, Misun Hwang

Abstract readReview
In one paragraph

Review in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura May DavisClinical Research Core, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0009-0006-9901-9634
Misun HwangClinical Research Core, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-0125-2686

Funding

Novel Ultrasound Indices of Intracranial Pressure and Brain Ischemia in Neonatal HydrocephalusR01NS119473 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Misun Hwang · 2020 to 2026
$4.0M
Eye as a Window into Brain Health in Pediatric HydrocephalusR01NS126469 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Misun Hwang · 2023 to 2026
$2.7M
NINDS NIH HHS R01 NS119473NINDS NIH HHS R01 NS126469
6 · The paper itself

Abstract

Hemorrhagic hydrocephalus is a common pathology in neonates with high mortality and morbidity. Current imaging approaches fail to capture the mechanisms behind its pathogenesis. Here, we discuss the processes underlying this pathology, the metabolic dysfunction that occurs as a result, and the ways in which these metabolic changes inform novel methods of clinical imaging. The imaging advances described allow earlier detection of the cellular and metabolic changes, leading to better outcomes for affected neonates.

Indexed as

contrast-enhanced ultrasoundhydrocephalusproteomicssuper-resolution imaging

Identifiers

PMID39195508
PMCPMC11356463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.