Evidence map›Paper›PMID 39195502›Full record

ArticleMetabolites2024

Serum Metabolomics and NF-κB Pathway Analysis Revealed the Antipyretic Mechanism of Ellagic Acid on LPS-Induced Fever in Rabbits.

Feng-Feng Xie, Li-Ba Xu, Hua Zhu, Xiu-Qi Yu, Lin-Yu Deng, Hui-Zhen Qin, Si Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. A Triterpenoid-Enriched GLE70 Fraction FromFood science & nutrition · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Feng-Feng XieGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Li-Ba XuGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Hua ZhuGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Xiu-Qi YuGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Lin-Yu DengGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Hui-Zhen QinGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Si LinGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.

Funding

Doctoral Research Foundation Project of Guangxi University of Chinese Medicine 2023BS024Drug Safety Research Project Plan of units directly under Guangxi Directly under Guangxi Drug Administration (2023) 034Guangxi Science and Technology Program GuikeAB 21196016Guangxi Science and Technology Program GuikeAD 21238031The Basic Ability Enhancement Program for Young and Middle-aged Teachers of Guangxi 2022KY0286
6 · The paper itself

Abstract

Fever is one of the most common clinical conditions and is characterized by pyrogenic infection, malignancy, inflammation, and tissue damage, among others. Ellagic acid (EA) can inhibit the expression of related proteins on the pathway by blocking the nuclear factor kappa-B(NF-κB) signaling pathway, inhibit the levels of pro-inflammatory factors interleukin-1β(IL-1β), interleukin-6(IL-6), and tumor necrosis factor-α(TNF-α), increase the level of anti-inflammatory factor IL-10, and effectively alleviate inflammatory symptoms. In addition, EA can also reduce the levels of malondialdehyde(MDA) and nitric oxide(NO) in the body, increase the activities of superoxide dismutase (SOD), glutathione (GSH), and catalase(CAT), scavenge oxidative free radicals, inhibit lipid oxidation, and achieve antipyretic and anti-inflammatory effects. The purpose of this study was to establish the relationship between EA and various inflammatory markers, such as TNF-α, IL-6, IL-1β, prostaglandin E2(PGE

Indexed as

ellagic acidfevergas chromatography–mass spectroscopymetabolomicsNF-κB/COX-2

Identifiers

PMID39195502
PMCPMC11356007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.