Evidence map›Paper›PMID 39195466›Full record

ReviewMarine drugs2024

Voltage-Gated K

Rita Turcio, Francesca Di Matteo, Ilaria Capolupo, Tania Ciaglia, Simona Musella, Carla Di Chio, Claudio Stagno, Pietro Campiglia, Alessia Bertamino, Carmine Ostacolo

Abstract readReview
In one paragraph

Review in Marine drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rita TurcioDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
Francesca Di MatteoDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-9907-6472
Ilaria CapolupoDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
Tania CiagliaDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-6592-4373
Simona MusellaDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0001-8312-4241
Carla Di ChioDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, 98166 Messina, Italy.
Claudio StagnoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, 98166 Messina, Italy.ORCID 0000-0002-7994-8253
Pietro CampigliaDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-1069-2181
Alessia BertaminoDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
Carmine OstacoloDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0003-3715-8680

Funding

Italian Ministry for University and Research P2022YYTKF
6 · The paper itself

Abstract

Bioactive compounds are abundant in animals originating from marine ecosystems. Ion channels, which include sodium, potassium, calcium, and chloride, together with their numerous variants and subtypes, are the primary molecular targets of the latter. Based on their cellular targets, these venom compounds show a range of potencies and selectivity and may have some therapeutic properties. Due to their potential as medications to treat a range of (human) diseases, including pain, autoimmune disorders, and neurological diseases, marine molecules have been the focus of several studies over the last ten years. The aim of this review is on the various facets of marine (or marine-derived) molecules, ranging from structural characterization and discovery to pharmacology, culminating in the development of some "novel" candidate chemotherapeutic drugs that target potassium channels.

Indexed as

Marine ToxinsPotassium Channels, Voltage-GatedAnimalsAquatic OrganismsDrug DiscoveryHumansMarine ToxinsPotassium Channels, Voltage-Gateddisease treatingmarine toxinspeptidesvoltage-gated potassium channels

Identifiers

PMID39195466
PMCPMC11355921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.