ArticleCurrent oncology (Toronto, Ont.)2024
Radiation-Induced Lymphopenia and Its Impact on Survival in Patients with Brain Metastasis.
Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Integrating Physical Activity and Family Health Education into Pediatric Oncology Outpatient Care: ATIVAONCO Project.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- No Evidence for Depletion of Circulating Lymphocyte Populations in Primary Brain Tumor Patients Receiving Radiation Therapy Alone.International journal of radiation oncology, biology, physics · 2026Article
- Primary Intracranial Squamous Cell Carcinoma Arising from an Epidermoid Cyst: Successful Management with Subtotal Resection and Gamma Knife Radiosurgery in an Elderly Patient.Current oncology (Toronto, Ont.) · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundDifferences in radiation-induced lymphopenia and prognosis between methods of radiotherapy (RT) for brain metastases remain unclear.
methodsIn this retrospective analysis of patients who underwent whole-brain radiotherapy (WBRT) or stereotactic radiosurgery/radiotherapy (SRS/SRT) for brain metastases, baseline total lymphocyte count (TLC) data were obtained within 2 weeks before RT initiation. Follow-up TLC data were evaluated at 0-2, 2-4, and 4-8 weeks after RT completion. Persistent lymphopenia was defined as <800/μL at any time point.
resultsOverall, 138 RT courses in 128 patients were eligible (94 WBRT; 44 SRS/SRT). In the WBRT courses, the median baseline TLC was 1325/μL (IQR: 923-1799). Follow-up TLC decreased significantly to 946/μL (626-1316), 992/μL (675-1291), and 1075/μL (762-1435) (
conclusionThis study suggests SRS/SRT might be preferable for lymphocyte preservation in brain metastasis patients.
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