Evidence map›Paper›PMID 39195312›Full record

ArticleCurrent oncology (Toronto, Ont.)2024

Prior Negative Biopsy, PSA Density, and Anatomic Location Impact Cancer Detection Rate of MRI-Targeted PI-RADS Index Lesions.

Ahmad N Alzubaidi, Amy Zheng, Mohammad Said, Xuanjia Fan, Michael Maidaa, R Grant Owens, Max Yudovich, Suraj Pursnani, R Scott Owens, Thomas Stringer and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ahmad N AlzubaidiDepartment of Urology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Amy ZhengPennsylvania State College of Medicine, Hershey, PA 17033, USA.
Mohammad SaidDepartment of Urology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Xuanjia FanPennsylvania State College of Medicine, Hershey, PA 17033, USA.
Michael MaidaaDepartment of Urology, University of Florida College of Medicine, Gainesville, FL 32611, USA.
R Grant OwensDepartment of Urology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Max YudovichDepartment of Urology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.ORCID 0000-0002-5242-576X
Suraj PursnaniDepartment of Urology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
R Scott OwensUPMC Central PA Hospital, Camphill, PA 17011, USA.
Thomas StringerDepartment of Urology, University of Florida College of Medicine, Gainesville, FL 32611, USA.
Chad R TracyDepartment of Urology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Jay D RamanDepartment of Urology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMRI fusion prostate biopsy has improved the detection of clinically significant prostate cancer (CSC). Continued refinements in predicting the pre-biopsy probability of CSC are essential for optimal patient counseling. We investigated potential factors related to improved cancer detection rates (CDR) of CSC in patients with PI-RADS ≥ 3 lesions.

methodsThe pathology of 980 index lesions in 980 patients sampled by transrectal mpMRI-targeted prostate biopsy across four medical centers between 2017-2020 was reviewed. PI-RADS lesion distribution included 291 PI-RADS-5, 374 PI-RADS-4, and 315 PI-RADS-3. We compared CDR of index PI-RADS ≥ 3 lesions based on location (TZ) vs. (PZ), PSA density (PSAD), and history of prior negative conventional transrectal ultrasound-guided biopsy (TRUS).

resultsMean age, PSA, prostate volume, and level of prior negative TRUS biopsy were 66 years (43-90), 7.82 ng/dL (5.6-11.2), 54 cm

conclusionsFor index PI-RADS ≥ 3 lesions, CDR varied significantly based on location, prior history of negative TRUS biopsy, and PSAD. Such considerations are critical when counseling on the merits and potential yield of prostate needle biopsy.

Indexed as

Image-Guided BiopsyMagnetic Resonance ImagingProstate-Specific AntigenProstatic NeoplasmsAdultAgedAged, 80 and overHumansMaleMiddle AgedProstateRetrospective StudiesProstate-Specific Antigenfusion prostate biopsymagnetic resonance imagingPI-RADSPSA density

Identifiers

PMID39195312
PMCPMC11353048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.