Evidence map›Paper›PMID 39195285›Full record

ArticleCells2024

Impact of Neuroendocrine Differentiation (NED) on Enzalutamide and Abiraterone Efficacy in Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Retrospective Analysis.

Giovanni Farinea, Mariangela Calabrese, Federica Carfì, Isabella Saporita, Stefano Poletto, Marco Donatello Delcuratolo, Fabio Turco, Marco Audisio, Francesco Rosario Di Stefano, Marcello Tucci and 1 more

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giovanni FarineaDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.
Mariangela CalabreseDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.
Federica CarfìDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.
Isabella SaporitaDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.
Stefano PolettoDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.ORCID 0000-0002-0404-9683
Marco Donatello DelcuratoloDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.ORCID 0000-0003-3151-9166
Fabio TurcoOncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland.ORCID 0000-0003-3111-7888
Marco AudisioDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.
Francesco Rosario Di StefanoDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.
Marcello TucciDepartment of Medical Oncology, Cardinal Massaia Hospital, 14100 Asti, Italy.
Consuelo ButtiglieroDepartment of Oncology, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy.ORCID 0000-0002-2877-2518

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine differentiation (NED) represents a possible androgen receptor pathway inhibitors (ARPI) resistance mechanism in metastatic castration resistance prostate cancer (mCRPC). As mCRPC with NED has been excluded from clinical trials evaluating ARPI efficacy, this study investigates the prognostic impact of NED in mCRPC patients treated with ARPIs.

Indexed as

AndrostenesBenzamidesNitrilesPhenylthiohydantoinProstatic Neoplasms, Castration-ResistantAgedAged, 80 and overCell DifferentiationHumansMaleMiddle AgedNeoplasm MetastasisNeuroendocrine CellsRetrospective StudiesTreatment OutcomeabirateroneAndrostenesBenzamidesenzalutamideNitrilesPhenylthiohydantoinandrogen receptor pathway inhibitorcastration-resistant prostate cancerneuroendocrine tumorsprostate cancer

Identifiers

PMID39195285
PMCPMC11352349

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.