Evidence map›Paper›PMID 39195270›Full record

ReviewCells2024

Molecular Susceptibility and Treatment Challenges in Melanoma.

Kiran Kumar Kolathur, Radhakanta Nag, Prathvi V Shenoy, Yagya Malik, Sai Manasa Varanasi, Ramcharan Singh Angom, Debabrata Mukhopadhyay

Abstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Advances in pyrazolo[1,5-RSC advances · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kiran Kumar KolathurDepartment of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India.ORCID 0000-0003-4173-0977
Radhakanta NagDepartment of Microbiology, College of Basic Science & Humanities, Odisha University of Agriculture & Technology (OUAT), Bhubaneswar 751003, Odisha, India.ORCID 0000-0001-8456-5487
Prathvi V ShenoyDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India.ORCID 0009-0005-9205-7745
Yagya MalikDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India.
Sai Manasa VaranasiDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
Ramcharan Singh AngomDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-5894-1108
Debabrata MukhopadhyayDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-1858-5054

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is the most aggressive subtype of cancer, with a higher propensity to spread compared to most solid tumors. The application of OMICS approaches has revolutionized the field of melanoma research by providing comprehensive insights into the molecular alterations and biological processes underlying melanoma development and progression. This review aims to offer an overview of melanoma biology, covering its transition from primary to malignant melanoma, as well as the key genes and pathways involved in the initiation and progression of this disease. Utilizing online databases, we extensively explored the general expression profile of genes, identified the most frequently altered genes and gene mutations, and examined genetic alterations responsible for drug resistance. Additionally, we studied the mechanisms responsible for immune checkpoint inhibitor resistance in melanoma.

Indexed as

MelanomaDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansImmune Checkpoint InhibitorsMutationImmune Checkpoint InhibitorsBRAF inhibitorsBRAF mutationsimmunotherapyMEK inhibitorsmelanoma

Identifiers

PMID39195270
PMCPMC11352263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.