Evidence map›Paper›PMID 39195170›Full record

ArticleDiseases (Basel, Switzerland)2024

Evaluating Immunologic and Illness Outcomes of SARS-CoV-2 Infection in Vaccinated and Unvaccinated Children Aged ≥ 5 Years, in a Multisite Longitudinal Cohort.

Cynthia Porter, Zoe L Lyski, Jennifer L Uhrlaub, Katherine D Ellingson, Zuha Jeddy, Lisa Gwynn, Patrick Rivers, Ryan Sprissler, Kurt T Hegmann, Melissa M Coughlin and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diseases (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Cynthia PorterDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0001-9232-0279
Zoe L LyskiImmunobiology, College of Medicine-Tucson, University of Arizona, Health Sciences, Tucson, AZ 85724, USA.ORCID 0000-0003-3631-8072
Jennifer L UhrlaubImmunobiology, College of Medicine-Tucson, University of Arizona, Health Sciences, Tucson, AZ 85724, USA.ORCID 0000-0002-7745-0179
Katherine D EllingsonDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0001-7624-312X
Zuha JeddyAbt Associates, Rockville, MD 20852, USA.
Lisa GwynnLeonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Patrick RiversFamily and Community Medicine, College of Medicine-Tucson, University of Arizona Health Sciences, Tucson, AZ 85711, USA.ORCID 0000-0001-5195-518X
Ryan SprisslerCenter for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, AZ 85721, USA.
Kurt T HegmannRocky Mountain Center for Occupational and Environmental Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, UT 84111, USA.
Melissa M CoughlinCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Ashley L FowlkesInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
James HollisterDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0002-4328-1071
Lindsay LeClairAbt Associates, Rockville, MD 20852, USA.
Josephine MakCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Shawn C BeitelDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.
Sammantha FullerAbt Associates, Rockville, MD 20852, USA.
Pearl Q ZhengAbt Associates, Rockville, MD 20852, USA.
Molly VaughanAbt Associates, Rockville, MD 20852, USA.
Ramona P RaiAbt Associates, Rockville, MD 20852, USA.ORCID 0000-0003-3225-6919
Lauren GrantInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Gabriella Newes-AdeyiAbt Associates, Rockville, MD 20852, USA.ORCID 0000-0002-4411-0370
Young M YooInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.ORCID 0000-0002-0845-2293
Lauren OlshoAbt Associates, Rockville, MD 20852, USA.ORCID 0000-0003-4503-9745
Jefferey L BurgessDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0003-2362-9509
Alberto J Caban-MartinezLeonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-5960-1308
Sarang K YoonRocky Mountain Center for Occupational and Environmental Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, UT 84111, USA.
Amadea BrittonCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Manjusha GaglaniBaylor Scott & White Health, Texas A&M University College of Medicine, Temple, TX 76508, USA.
Andrew L PhillipsRocky Mountain Center for Occupational and Environmental Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, UT 84111, USA.
Matthew S ThieseRocky Mountain Center for Occupational and Environmental Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, UT 84111, USA.ORCID 0000-0003-4505-2907
Melissa Briggs HagenCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Jefferson M JonesCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Karen LutrickFamily and Community Medicine, College of Medicine-Tucson, University of Arizona Health Sciences, Tucson, AZ 85711, USA.ORCID 0000-0003-3480-849X

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
NCATS NIH HHS UM1 TR004409NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

Hybrid immunity, as a result of infection and vaccination to SARS-CoV-2, has been well studied in adults but limited evidence is available in children. We evaluated the antibody responses to primary SARS-CoV-2 infection among vaccinated and unvaccinated children aged ≥ 5 years.

methodsA longitudinal cohort study of children aged ≥ 5 was conducted during August 2021-August 2022, at sites in Arizona, Texas, Utah, and Florida. Children submitted weekly nasal swabs for PCR testing and provided sera 14-59 days after PCR-confirmed SARS-CoV-2 infection. Antibodies were measured by ELISA against the receptor-binding domain (RBD) and S2 domain of ancestral Spike (WA1), in addition to Omicron (BA.2) RBD, following infection in children, with and without prior monovalent ancestral mRNA COVID-19 vaccination.

resultsAmong the 257 participants aged 5 to 18 years, 166 (65%) had received at least two mRNA COVID-19 vaccine doses ≥ 14 days prior to infection. Of these, 53 occurred during Delta predominance, with 37 (70%) unvaccinated at the time of infection. The remaining 204 infections occurred during Omicron predominance, with 53 (26%) participants unvaccinated. After adjusting for weight, age, symptomatic infection, and gender, significantly higher mean RBD AUC values were observed among the vaccinated group compared to the unvaccinated group for both WA1 and Omicron (

conclusionsChildren with vaccine-induced immunity at the time of SARS-CoV-2 infection had higher antibody levels during convalescence and experienced less fever compared to unvaccinated children during infection.

Indexed as

antibody responsechildreninfectionSARS-CoV-2vaccination

Identifiers

PMID39195170
PMCPMC11354143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.