Evidence map›Paper›PMID 39195144›Full record

ArticleJournal of cardiovascular development and disease2024

Compromised Cerebral Arterial Perfusion, Altered Brain Tissue Integrity, and Cognitive Impairment in Adolescents with Complex Congenital Heart Disease.

Nancy A Pike, Bhaswati Roy, Cristina Cabrera-Mino, Nancy J Halnon, Alan B Lewis, Xingfeng Shao, Danny J J Wang, Rajesh Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular development and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Placental-Heart Axis: An Evolutionary Perspective.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nancy A PikeSue & Bill Gross School of Nursing, University of California Irvine, Irvine, CA 92697, USA.
Bhaswati RoyDepartments of Anesthesiology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Cristina Cabrera-MinoSchool of Nursing, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8758-7331
Nancy J HalnonDivision of Pediatric Cardiology, Mattel Children's Hospital UCLA, Los Angeles, CA 90095, USA.
Alan B LewisDivision of Pediatric Cardiology, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Xingfeng ShaoLaboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-4130-6204
Danny J J WangLaboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-0840-7062
Rajesh KumarDepartments of Anesthesiology, Radiological Sciences & Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.

Funding

Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart DiseaseR01NR016463 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, PIKE, NANCY ANN · 2016 to 2019
$2.0M
Brain Metabolites, Brain Antioxidant, and Cerebral Blood Flow Deficits in Single Ventricle Heart DiseaseR21NS131850 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, PIKE, NANCY ANN · 2023 to 2024
$429k
Sex Differences in Psychosocial and Neurocognitive Outcomes in Adults with Moderate to Complex Congenital Heart DiseaseF31NR020976 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CABRERA-MINO, CRISTINA · 2023 to 2025
$73k
NIH HHS R01 NR016463-01NINDS NIH HHS R21 NS131850NINR NIH HHS F31 NR020976NINR NIH HHS R01 NR016463
6 · The paper itself

Abstract

(1) Introduction: Adolescents with complex congenital heart disease (CCHD) show brain tissue injuries in regions associated with cognitive deficits. Alteration in cerebral arterial perfusion (CAP), as measured by arterial transit time (ATT), may lead to perfusion deficits and potential injury. Our study aims to compare ATT values between CCHD patients and controls and assess the associations between ATT values, MD values, and cognitive scores in adolescents with CCHD. (2) Methods: 37 CCHD subjects, 14-18 years of age, who had undergone surgical palliation and 30 healthy controls completed cognitive testing and brain MRI assessments using a 3.0-Tesla scanner. ATT values and regional brain mean diffusivity [MD] were assessed for the whole brain using diffusion tensor imaging. (3) Results: The mean MoCA values [23.1 ± 4.1 vs. 28.1 ± 2.3;

Indexed as

arterial transit timemagnetic resonance imagingmemorysingle ventricle

Identifiers

PMID39195144
PMCPMC11354402

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.