Evidence map›Paper›PMID 39195036›Full record

ReviewGels (Basel, Switzerland)2024

A Review on the Rheological Properties of Single Amino Acids and Short Dipeptide Gels.

Sérgio R S Veloso, Mariangela Rosa, Carlo Diaferia, Célio Fernandes

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sérgio R S VelosoPhysics Centre of Minho and Porto Universities (CF-UM-UP), Laboratory of Physics for Materials and Emergent Technologies (LaPMET), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0003-2724-5772
Mariangela RosaDepartment of Pharmacy, Centro Interuniversitario di Ricerca sui Peptidi Bioattivi "Carlo Pedone" (CIRPeB), University of Naples "Federico II", Via Tommaso de Amicis 95, 80131 Naples, Italy.
Carlo DiaferiaDepartment of Pharmacy, Centro Interuniversitario di Ricerca sui Peptidi Bioattivi "Carlo Pedone" (CIRPeB), University of Naples "Federico II", Via Tommaso de Amicis 95, 80131 Naples, Italy.ORCID 0000-0002-9273-0136
Célio FernandesTransport Phenomena Research Centre (CEFT), Department of Mechanical Engineering, Faculty of Engineering, University of Porto (FEUP), Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal.ORCID 0000-0002-0340-3556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembled peptide-based hydrogels have attracted considerable interest from the research community. Particularly, low molecular weight gelators (LMWGs) consisting of amino acids and short peptides are highly suitable for biological applications owing to their facile synthesis and scalability, as well as their biocompatibility, biodegradability, and stability in physiological conditions. However, challenges in understanding the structure-property relationship and lack of design rules hinder the development of new gelators with the required properties for several applications. Hereby, in the plethora of peptide-based gelators, this review discusses the mechanical properties of single amino acid and dipeptide-based hydrogels. A mutual analysis of these systems allows us to highlight the relationship between the gel mechanical properties and amino acid sequence, preparation methods, or N capping groups. Additionally, recent advancements in the tuning of the gels' rheological properties are reviewed. In this way, the present review aims to help bridge the knowledge gap between structure and mechanical properties, easing the selection or design of peptides with the required properties for biological applications.

Indexed as

amino acid hydrogelsmechanical propertiespeptide hydrogelspeptide materialsself-assembly

Identifiers

PMID39195036
PMCPMC11354022

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.