Evidence map›Paper›PMID 39194742›Full record

ArticleCurrent issues in molecular biology2024

Dysregulated Inflammatory Cytokine Levels May Be Useful Markers in a Better Up-Dated Management of COVID-19.

Marco Iuliano, Roberta Maria Mongiovì, Alberico Parente, Blerta Kertusha, Anna Carraro, Raffaella Marocco, Giulia Mancarella, Cosmo Del Borgo, Laura Fondaco, Lorenzo Grimaldi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marco IulianoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-3862-9731
Roberta Maria MongiovìDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98122 Messina, Italy.
Alberico ParenteDepartment of Public Health and Infectious Disease, S. Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.
Blerta KertushaDepartment of Public Health and Infectious Disease, S. Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.
Anna CarraroDepartment of Public Health and Infectious Disease, S. Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0001-7399-5262
Raffaella MaroccoDepartment of Public Health and Infectious Disease, S. Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.
Giulia MancarellaDepartment of Public Health and Infectious Disease, S. Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.
Cosmo Del BorgoDepartment of Public Health and Infectious Disease, S. Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.
Laura FondacoDepartment of Public Health and Infectious Disease, S. Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.
Lorenzo GrimaldiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
Maria DorrucciDepartment of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
Miriam LichtnerDepartment of General Surgery and Surgical Specialty, Sapienza University of Rome, 00168 Rome, Italy.ORCID 0000-0002-7730-3953
Giorgio ManginoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-8950-9780
Giovanna RomeoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-7638-1001

Funding

Fondo integrativo speciale per la ricerca (FISR) FISR2020IP_02955
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is an infection characterized by the dysregulation of systemic cytokine levels. The measurement of serum levels of inflammatory cyto-/chemokines has been suggested as a tool in the management of COVID-19. The aim of this study is to highlight the significance of measured levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12(p70), IL-27, interferon (IFN)γ, interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and tumor necrosis factor (TNF)-α in serum samples from infected and recovered subjects, possibly predictive of severity and/or duration of the disease. Serum samples from healthy (HD), positive at hospital admittance (T0), and recovered subjects (T1, 31-60, or 70-200 days post-negativization) were collected and tested through a bead-based cytometric assay and confirmed through ELISA. IL-10 levels were increased in the T0 group compared to both HD and T1. IL-27 significantly decreased in the 31-60 group. IL-1β significantly increased in the 70-200 day group. TNF-α significantly decreased in T0 compared to HD and in the 31-60 group versus HD. IP-10 significantly increased in T0 compared to HD. These results suggest that IP-10 could represent an early marker of clinical worsening, whereas IL-10 might be indicative of the possible onset of post-COVID-19 long syndrome.

Indexed as

IL-10inflammatory mediatorsIP-10SARS-CoV-2

Identifiers

PMID39194742
PMCPMC11352939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.