Evidence map›Paper›PMID 39194701›Full record

ArticleCurrent issues in molecular biology2024

Rising Prevalence of Low-Frequency

Katja Seipel, Nuria Z Veglio, Henning Nilius, Barbara Jeker, Ulrike Bacher, Thomas Pabst

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Low-FrequencyCancers · 2026
    Article
  2. Influence ofBiomedicines · 2026
    Article
  3. Review
  4. Elevated Allele Frequency and Male-Predominance of a CommonCurrent issues in molecular biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katja SeipelDepartment for Biomedical Research, University of Bern, 3008 Bern, Switzerland.ORCID 0000-0003-3128-1573
Nuria Z VeglioDepartment of Medical Oncology, University Hospital Bern, 3010 Bern, Switzerland.
Henning NiliusDepartment of Clinical Chemistry, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-1323-3116
Barbara JekerDepartment of Medical Oncology, University Hospital Bern, 3010 Bern, Switzerland.
Ulrike BacherDepartment of Hematology, University Hospital Bern, 3010 Bern, Switzerland.ORCID 0000-0001-8771-947X
Thomas PabstDepartment of Medical Oncology, University Hospital Bern, 3010 Bern, Switzerland.ORCID 0000-0002-6055-5257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma (MM) first-line treatment algorithms include immuno-chemotherapy (ICT) induction, high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) consolidation, followed by lenalidomide maintenance. After these initial therapies, most patients suffer a disease relapse and require subsequent treatment lines including ICT, additional HDCT and ASCT, or novel immunotherapies. The presence of somatic mutations in peripheral blood cells has been associated with adverse outcomes in a variety of hematological malignancies. Nonsense and frameshift mutations in the

Indexed as

autologous stem cell transplant (ASCT)clonal hematopoiesis (CH)multiple myeloma (MM)next-generation sequencing (NGS)protein phosphatase Mg/Mn-dependent 1D (PPM1D)wild-type p53-induced phosphatase 1 (Wip1)

Identifiers

PMID39194701
PMCPMC11353243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.