Cationic Serine-Based Gemini Surfactant:Monoolein Aggregates as Viable and Efficacious Agents for DNA Complexation and Compaction: A Cytotoxicity and Physicochemical Assessment.

Isabel S Oliveira, Sandra G Silva, Andreia C Gomes, M Elisabete C D Real Oliveira, M Luísa C do Vale, Eduardo F Marques

Abstract read

In one paragraph

Article in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isabel S OliveiraCIQUP (Centro de Investigação em Química da Universidade do Porto), IMS (Institute of Molecular Sciences), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.ORCID 0000-0002-0515-9470

Sandra G SilvaLAQV-REQUIMTE (Laboratório Associado para a Química Verde-Rede Química e Tecnologia), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.ORCID 0000-0001-7254-390X

Andreia C GomesCBMA (Centro de Biologia Molecular e Ambiental), Departamento de Biologia, Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-0567-064X

M Elisabete C D Real OliveiraCFUM (Center of Physics), Departamento de Física, Universidade do Minho, Campos de Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-9728-8172

M Luísa C do ValeLAQV-REQUIMTE (Laboratório Associado para a Química Verde-Rede Química e Tecnologia), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.ORCID 0000-0002-8967-6642

Eduardo F MarquesCIQUP (Centro de Investigação em Química da Universidade do Porto), IMS (Institute of Molecular Sciences), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.ORCID 0000-0002-3892-9216

Funding

Fundação para a Ciência e para a Tecnologia 2022.05543.PTDCFundação para a Ciência e para a Tecnologia LA/P/0056/2020Fundação para a Ciência e para a Tecnologia UIDB/00081/2020Fundação para a Ciência e para a Tecnologia UIDB/50006/2020Fundação para a Ciência e para a Tecnologia UIDP/50006/2020

6 · The paper itself

Abstract

Cationic gemini surfactants have emerged as potential gene delivery agents as they can co-assemble with DNA due to a strong electrostatic association. Commonly, DNA complexation is enhanced by the inclusion of a helper lipid (HL), which also plays a key role in transfection efficiency. The formation of lipoplexes, used as non-viral vectors for transfection, through electrostatic and hydrophobic interactions is affected by various physicochemical parameters, such as cationic surfactant:HL molar ratio, (+/-) charge ratio, and the morphological structure of the lipoplexes. Herein, we investigated the DNA complexation ability of mixtures of serine-based gemini surfactants, (nSer)

Indexed as

chain lengthDNA complexation/compactiongemini surfactantshelper lipidlipoplexmonooleinnon-viral gene deliveryserine

Identifiers

PMID39194661

DOI10.3390/jfb15080224

PMCPMC11355309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.