Evidence map›Paper›PMID 39194647›Full record

ArticleJournal of functional biomaterials2024

Luteinizing Hormone-Releasing Hormone (LHRH)-Conjugated Cancer Drug Delivery from Magnetite Nanoparticle-Modified Microporous Poly-Di-Methyl-Siloxane (PDMS) Systems for the Targeted Treatment of Triple Negative Breast Cancer Cells.

Stanley C Eluu, John D Obayemi, Danyuo Yiporo, Ali A Salifu, Augustine O Oko, Killian Onwudiwe, Toyin Aina, Josephine C Oparah, Chukwudi C Ezeala, Precious O Etinosa and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stanley C EluuDepartment of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University, Ifite Awka 420110, Nigeria.ORCID 0000-0003-2425-6249
John D ObayemiDepartment of Mechanical and Material Science Engineering, Higgins Lab, Worcester Polytechnic Institute (WPI), 100 Institute Road, Worcester, MA 01609, USA.ORCID 0000-0002-0324-5957
Danyuo YiporoDepartment of Mechanical Engineering, Ashesi University, Berekuso PMB CT3, Ghana.
Ali A SalifuDepartment of Engineering, Morrissey College of Arts and Science, Boston College, Chestnut Hill, MA 02467, USA.
Augustine O OkoDepartment of Biotechnology, Ebonyi State University, Abakaliki 480101, Nigeria.
Killian OnwudiweAerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Toyin AinaDepartment of Biomedical Engineering, Collage of Engineering, Afe Babalola University, KM 8.5 Afe Babalola Way, Ado-Ekiti 360001, Nigeria.
Josephine C OparahDepartment of Material Science, African University of Science and Technology, Km 10 Airport Road, Abuja 900107, Nigeria.
Chukwudi C EzealaDepartment of Material Science, African University of Science and Technology, Km 10 Airport Road, Abuja 900107, Nigeria.
Precious O EtinosaDepartment of Mechanical and Material Science Engineering, Higgins Lab, Worcester Polytechnic Institute (WPI), 100 Institute Road, Worcester, MA 01609, USA.ORCID 0000-0003-4032-8839
Sarah A OsafoDepartment of Material Science and Engineering, University of Ghana, Legon, Accra P.O. Box LG 1181, Ghana.
Malachy C UgwuDepartment of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University, Ifite Awka 420110, Nigeria.
Charles O EsimoneDepartment of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University, Ifite Awka 420110, Nigeria.
Winston O SoboyejoDepartment of Mechanical and Material Science Engineering, Higgins Lab, Worcester Polytechnic Institute (WPI), 100 Institute Road, Worcester, MA 01609, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents LHRH conjugated drug delivery via a magnetite nanoparticle-modified microporous Poly-Di-Methyl-Siloxane (PDMS) system for the targeted suppression of triple-negative breast cancer cells. First, the MNP-modified PDMS devices are fabricated before loading with targeted and untargeted cancer drugs. The release kinetics from the devices are then studied before fitting the results to the Korsmeyer-Peppas model. Cell viability and cytotoxicity assessments are then presented using results from the Alamar blue assay. Apoptosis induction is then elucidated using flow cytometry. The in vitro drug release studies demonstrated a sustained and controlled release of unconjugated drugs (Prodigiosin and paclitaxel) and conjugated drugs [LHRH conjugated paclitaxel (PTX+LHRH) and LHRH-conjugated prodigiosin (PG+LHRH)] from the magnetite nanoparticle modified microporous PDMS devices for 30 days at 37 °C, 41 °C, and 44 °C. At 24, 48, 72, and 96 h, the groups loaded with conjugated drugs (PG+LHRH and PTX+LHRH) had a significantly higher (

Indexed as

cell viabilityconjugated drugsmagnetitepoly-di-methyl-siloxane (PDMS)sustained drug releasetargeted and localized treatmenttriple-negative breast cancer

Identifiers

PMID39194647
PMCPMC11355790

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.