Evidence map›Paper›PMID 39194344›Full record

ArticleCancer medicine2024

On the informative value of community-based indoor radon values in relation to lung cancer.

Albert Rosenberger, Heike Bickeböller, David C Christiani, Geoffrey Liu, Matthew B Schabath, Luisa F Duarte, Loic Le Marchand, Christopher Haiman, Teresa Landi, Dario Consonni and 8 more

Abstract read
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Radiophobia Harm, Its Main Cause, and a Proposed Solution.Dose-response : a publication of International Hormesis Society
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Albert RosenbergerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.ORCID 0000-0001-7848-1332
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.ORCID 0000-0002-3361-5488
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-0301-0242
Geoffrey LiuMedical Oncology and Medical Biophysics, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0002-2603-7296
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID 0000-0003-3241-3216
Luisa F DuarteDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.ORCID 0000-0001-5013-980X
Christopher HaimanCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-0097-9971
Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-9727-7772
Dario ConsonniEpidemiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy.ORCID 0000-0002-8935-3843
John K FieldDepartment of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool, Liverpool, UK.ORCID 0000-0003-3951-6365
Michael P A DaviesDepartment of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool, Liverpool, UK.ORCID 0000-0002-7609-4977
Demetrios AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Adonina TardónFaculty of Medicine, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain.ORCID 0000-0001-5150-1209
Guillermo Fernández-TardónFaculty of Medicine, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain.ORCID 0000-0002-7680-158X
Gad RennertClalit National Cancer Control Center and Department of Community Medicine and Epidemiology at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.ORCID 0000-0002-8512-068X
Christopher I AmosDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-8540-7023
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-4486-7496

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Translating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Rayjean J. Hung · 2017 to 2026
$23.7M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
NCI NIH HHS R35 CA197449NCI NIH HHS U19 CA203654NIEHS NIH HHS P30 ES000002NIH HHS 7U19CA203654-02/ 397 114564-5111078
6 · The paper itself

Abstract

backgroundRadon is a radioactive gas and a major risk factor for lung cancer (LC).

methodsWe investigated the dose-response relationship between radon and LC risk in the International Lung Cancer Consortium with 8927 cases and 5562 controls from Europe, North America, and Israel, conducted between 1992 and 2016. Spatial indoor radon exposure in the residential area (sIR) obtained from national surveys was linked to the participants' residential geolocation. Parametric linear and spline functions were fitted within a logistic regression framework.

resultsWe observed a non-linear spatial-dose response relationship for sIR < 200 Bq/m

conclusionsThe sIR is useful as proxy of individual radon exposure in epidemiological studies on lung cancer. The usual assumption of a linear, no-threshold dose-response relationship, as can be made for individual radon exposures, may not be optimal for sIR values of less than 200 Bq/m

Indexed as

Air Pollution, IndoorLung NeoplasmsRadonAdultAgedAir Pollutants, RadioactiveCase-Control StudiesDose-Response Relationship, RadiationEuropeFemaleHumansIsraelMaleMiddle AgedNeoplasms, Radiation-InducedNorth AmericaAir Pollutants, RadioactiveRadonhistological subtypeslung cancerradiationsmoking

Identifiers

PMID39194344
PMCPMC11350838

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.