Evidence map›Paper›PMID 39194290›Full record

ArticleMicrobiology spectrum2024

The role of exopolysaccharides Psl and Pel in resistance of

Waleska S da Cruz Nizer, Kira N Allison, Madison E Adams, Mario A Vargas, Duale Ahmed, Carole Beaulieu, Deepa Raju, Edana Cassol, P Lynne Howell, Joerg Overhage

Abstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. UnderstandingMicroorganisms · 2026
    Review
  5. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Activity of Antiseptics AgainstAntibiotics (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Waleska S da Cruz NizerDepartment of Health Sciences, Carleton University, Ottawa, Ontario, Canada.
Kira N AllisonDepartment of Health Sciences, Carleton University, Ottawa, Ontario, Canada.
Madison E AdamsDepartment of Health Sciences, Carleton University, Ottawa, Ontario, Canada.
Mario A VargasProgram in Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Duale AhmedDepartment of Health Sciences, Carleton University, Ottawa, Ontario, Canada.
Carole BeaulieuDepartment of Health Sciences, Carleton University, Ottawa, Ontario, Canada.
Deepa RajuProgram in Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Edana CassolDepartment of Health Sciences, Carleton University, Ottawa, Ontario, Canada.
P Lynne HowellProgram in Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-2776-062X
Joerg OverhageDepartment of Health Sciences, Carleton University, Ottawa, Ontario, Canada.ORCID 0009-0001-6721-2580

Funding

Canadian Government | Canadian Institutes of Health Research (CIHR) CIHR FDN 143327Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2019-06335
6 · The paper itself

Abstract

IMPORTANCE: Biofilms are microbial communities of cells embedded in a self-produced polymeric matrix composed of polysaccharides, proteins, lipids, and extracellular DNA. Biofilm bacteria have been shown to possess unique characteristics, including increased stress resistance and higher antimicrobial tolerance, leading to failures in bacterial eradication during chronic infections or in technical settings, including drinking and wastewater industries. Previous studies have shown that in addition to conferring structure and stability to biofilms, the polysaccharides Psl and Pel are also involved in antibiotic resistance. This work provides evidence that these biofilm matrix components also contribute to the resistance of

Indexed as

BiofilmsHydrogen PeroxideOxidative StressPolysaccharides, BacterialPseudomonas aeruginosaSodium HypochloriteAnti-Bacterial AgentsBacterial ProteinsDisinfectantsDrug Resistance, BacterialAnti-Bacterial AgentsBacterial ProteinsDisinfectantsexopolysaccharide, PseudomonasHydrogen PeroxidePolysaccharides, BacterialSodium Hypochloritebiofilmsexopolysaccharideshydrogen peroxideoxidative stressPseudomonas aeruginosareactive chlorine speciessodium hypochlorite

Identifiers

PMID39194290
PMCPMC11448232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.