Evidence map›Paper›PMID 39194262›Full record

ArticleAntimicrobial agents and chemotherapy2024

Loss of glycerol catabolism confers carbon-source-dependent artemisinin resistance in

Maria Carla Martini, Maria Natalia Alonso, Juan Hilario Cafiero, Junpei Xiao, Scarlet S Shell

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Genomic Insight into Primary Adaptation ofAntibiotics (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Carla Martini *Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
Maria Natalia Alonso *Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
Juan Hilario CafieroDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
Junpei XiaoProgram in Bioinformatics and Computational Biology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
Scarlet S ShellDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.ORCID 0000-0003-1136-1728

Funding

Surviving evolution: Short-term adaptations for fitnessP01AI143575 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SABINE EHRT · 2020 to 2026
$18.2M
The mechanistic basis of Artemisia annua activity against Mycobacterium tuberculosisR21AI151481 · NIAID · WORCESTER POLYTECHNIC INSTITUTE · PI SHELL, SCARLET SARA · 2020 to 2021
$435k
The roles of sRNA in the physiology and pathogenesis of Mycobacterium abscessus and other mycobacteriaR21AI156415 · NIAID · WORCESTER POLYTECHNIC INSTITUTE · PI SHELL, SCARLET SARA · 2021 to 2022
$395k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21 AI151481, 5P01AI143575-02, R21 AI156415-01A1NIAID NIH HHS P01 AI143575NIAID NIH HHS R21 AI151481NIAID NIH HHS R21 AI156415
6 · The paper itself

Abstract

In view of the urgent need for new antibiotics to treat human infections caused by multidrug-resistant pathogens, drug repurposing is gaining strength due to the relatively low research costs and shorter clinical trials. Such is the case of artemisinin, an antimalarial drug that has recently been shown to display activity against

Indexed as

Antitubercular AgentsArtemisininsGlycerolMicrobial Sensitivity TestsMycobacterium tuberculosisBacterial ProteinsCarbonDrug Resistance, BacterialHumansMutationWhole Genome SequencingAntitubercular AgentsartemisininArtemisininsBacterial ProteinsCarbonGlycerolartemisinindrug resistance mechanismsglpKglycerol kinaseglycerol metabolismMycobacterium tuberculosis

Identifiers

PMID39194262
PMCPMC11459938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.