Evidence map›Paper›PMID 39194208›Full record

ArticleAntimicrobial agents and chemotherapy2024

Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries.

Dario Akaberi, Monireh Pourghasemi Lati, Janina Krambrich, Julia Berger, Grace Neilsen, Emilia Strandback, S Pauliina Turunen, Johan Wannberg, Hjalmar Gullberg, Martin Moche and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Dario AkaberiDepartment of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-9595-9796
Monireh Pourghasemi LatiDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Janina KrambrichDepartment of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.
Julia BergerDepartment of Medical Sciences, Clinical Microbiology, Uppsala University, Uppsala, Sweden.
Grace NeilsenCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Emilia StrandbackDepartment of Medical Biochemistry and Biophysics, Protein Science Facility, Karolinska Institutet, Stockholm, Sweden.
S Pauliina TurunenDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.
Johan WannbergDepartment of Medicinal Chemistry, Science for Life Laboratory, BMC, Uppsala University, Uppsala, Sweden.
Hjalmar GullbergScience for Life Laboratory, Biochemical and Cellular Assay Facility, Drug Discovery and Development Platform, Department of Biochemistry and Biophysics, Stockholm University, Solna, Stockholm, Sweden.
Martin MocheDepartment of Medical Biochemistry and Biophysics, Protein Science Facility, Karolinska Institutet, Stockholm, Sweden.
Praveen Kumar ChinthakindiThe Beijer Laboratory, Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden.
Tomas NymanDepartment of Medical Biochemistry and Biophysics, Protein Science Facility, Karolinska Institutet, Stockholm, Sweden.
Stefan G SarafianosCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-5840-154X
Anja SandströmThe Beijer Laboratory, Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden.
Josef D JärhultDepartment of Medical Sciences, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.
Kristian SandbergScience for Life Laboratory, Drug Discovery & Development Platform, Uppsala University, Uppsala, Sweden.
Åke LundkvistDepartment of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.
Oscar VerhoDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-3153-748X
Johan LennerstrandDepartment of Medical Sciences, Clinical Microbiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-1093-0530

Funding

Erik, Karin and Gösta Selander Foundation 2021,2022Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) Nevermore CovidScandinavian Society for Antimicrobial Chemotherapy Foundation (SSAC Foundation) SLS-961049,SLS-974118Science for Life Laboratory (SciLifeLab) Nevermore CovidWenner-Gren Foundations ft2018-0002
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesSARS-CoV-2Small Molecule LibrariesCaco-2 CellsCOVID-19 Drug TreatmentCrystallography, X-RayHumansProtease Inhibitors3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesProtease InhibitorsSmall Molecule LibrariesantiviralscoronavirusesDNA-encoded chemical library (DECL)Mproprotease inhibitorsSARS-CoV-2

Identifiers

PMID39194208
PMCPMC11459923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.