Evidence map›Paper›PMID 39193720›Full record

ArticleAge and ageing2024

Surgical versus conservative treatment for odontoid fractures in older people: an international prospective comparative study.

Jeroen G J Huybregts, Samuel B Polak, Wilco C Jacobs, Mark P Arts, Bernhard Meyer, Maria Wostrack, Vicki M Butenschön, Michael Osti, F Cumhur Öner, Willem-Bart M Slooff and 14 more

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Age and ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Anterior Odontoid Screw Fixation: Current Advances in Indications and Techniques.Advances and technical standards in neurosurgery · 2026
    Review
  7. Article
  8. [Treatment of geriatric odontoid fractures].Unfallchirurgie (Heidelberg, Germany) · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Jeroen G J HuybregtsDepartment of Neurosurgery, University Neurosurgical Centre Holland, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0001-9095-3814
Samuel B PolakDepartment of Neurosurgery, University Neurosurgical Centre Holland, Leiden University Medical Centre, Leiden, The Netherlands.
Wilco C JacobsDepartment of Neurosurgical Research, The Health Scientist, The Hague, The Netherlands.
Mark P ArtsDepartment of Neurosurgery, University Neurosurgical Centre Holland, Haaglanden Medical Centre, The Hague, The Netherlands.
Bernhard MeyerDepartment of Neurosurgery, School of Medicine, Technical University Munich, Munchen, Germany.
Maria WostrackDepartment of Neurosurgery, School of Medicine, Technical University Munich, Munchen, Germany.
Vicki M ButenschönDepartment of Neurosurgery, School of Medicine, Technical University Munich, Munchen, Germany.
Michael OstiDepartment of Trauma Surgery and Sports Traumatology, Academic Hospital Feldkirch, Feldkirch, Austria.
F Cumhur ÖnerDepartments of Orthopaedics/Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Willem-Bart M SlooffDepartments of Orthopaedics/Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Ricardo E FellerDepartment of Neurosurgery, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Gert-Joan BoumaDepartment of Neurosurgery, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Biswadjiet S HarhangiDepartment of Neurosurgery, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.
Bart DepreitereDepartment of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.
Øystein P NygaardDepartment of Neurosurgery, St Olavs University Hospital, Trondheim, Norway.
Clemens WeberDepartment of Neurosurgery, Stavanger University Hospital, Stavanger, Norway.
Kay MüllerDepartment of Neurosurgery, University Hospital North Norway, Tromsø, Norway.
Jake TimothyDepartment of Neurosurgery, University of Leeds, UK.
Ferran PelliséSpine Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Mikkel M RasmussenDepartment of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Erik W van ZwetDepartment of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
Ewout W SteyerbergDepartment of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
Wilco C PeulDepartment of Neurosurgery, University Neurosurgical Centre Holland, Leiden University Medical Centre, Leiden, The Netherlands.
Carmen L A Vleggeert-LankampDepartment of Neurosurgery, University Neurosurgical Centre Holland, Leiden University Medical Centre, Leiden, The Netherlands.

Funding

EUROSPINE Start-up Grant
6 · The paper itself

Abstract

backgroundThe optimal treatment for odontoid fractures in older people remains debated. Odontoid fractures are increasingly relevant to clinical practice due to ageing of the population.

methodsAn international prospective comparative study was conducted in fifteen European centres, involving patients aged ≥55 years with type II/III odontoid fractures. The surgeon and patient jointly decided on the applied treatment. Surgical and conservative treatments were compared. Primary outcomes were Neck Disability Index (NDI) improvement, fracture union and stability at 52 weeks. Secondary outcomes were Visual Analogue Scale neck pain, Likert patient-perceived recovery and EuroQol-5D-3L at 52 weeks. Subgroup analyses considered age, type II and displaced fractures. Multivariable regression analyses adjusted for age, gender and fracture characteristics.

resultsThe study included 276 patients, of which 144 (52%) were treated surgically and 132 (48%) conservatively (mean (SD) age 77.3 (9.1) vs. 76.6 (9.7), P = 0.56). NDI improvement was largely similar between surgical and conservative treatments (mean (SE) -11 (2.4) vs. -14 (1.8), P = 0.08), as were union (86% vs. 78%, aOR 2.3, 95% CI 0.97-5.7) and stability (99% vs. 98%, aOR NA). NDI improvement did not differ between patients with union and persistent non-union (mean (SE) -13 (2.0) vs. -12 (2.8), P = 0.78). There was no difference for any of the secondary outcomes or subgroups.

conclusionsClinical outcome and fracture healing at 52 weeks were similar between treatments. Clinical outcome and fracture union were not associated. Treatments should prioritize favourable clinical over radiological outcomes.

Indexed as

Conservative TreatmentOdontoid ProcessSpinal FracturesAgedAged, 80 and overAge FactorsDisability EvaluationEuropeFemaleFracture FixationFracture HealingHumansMaleMiddle AgedNeck PainPain Measurementconservative treatmentodontoid fracturesolder peoplesurgical treatmenttreatment outcome

Identifiers

PMID39193720
PMCPMC11350288

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.